Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-10-03
2006-10-03
Wang, Anrew (Department: 1639)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C548S469000, C548S484000, C548S504000
Reexamination Certificate
active
07115753
ABSTRACT:
Disclosed are triaryl cationic compounds that exhibit broad spectrum antibiotic and antifungal activity, pharmaceutical compositions containing the compounds, and methods of treating bacterial and fungal infections using the compounds. The compounds were initially isolated by screening a 25,000-member bacterial artificial chromosome (BAC) library of environmental (eDNA) from soil. At least one clone produced a dark brown melanin-like compound that was found to have antibiotic activity. The compounds were isolated and synthesized de novo. From within the positive clone, a single open reading frame that shares extensive sequence similarity with members of the 4-hydroxyphenylpyruvate family of enzymes was found to be necessary and sufficient to confer the production of at least one of the subject compounds onE. coli.
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Bettermann Alan D.
Brady Sean F.
Clardy Jon C.
Gillespie Doreen E.
Goodman Robert M.
DeWitt Ross & Stevens S.C.
Epperson Jon D.
Leone, Esq. Joseph T.
Wang Anrew
Wisconsin Alumni Research Foundation
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