Triamine chelants, their derivatives, complexes and conjugates

Details Triamine chelants, their derivatives, complexes and conjugates Triamine chelants, their derivatives, complexes and conjugates

1991-05-09

1995-03-07

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to antibody or antibody fragment or immunoglobulin;...

424 169, 534 10, 534 14, 5303915, 564368, A61K 4900, A61K 3514, C07C21100

Patent

active

053956087

ABSTRACT:
A group of functionalized triamine chelants and their derivatives that form complexes with radioactive metal ions are disclosed. The complexes can be covalently attached to a protein or an antibody or antibody fragment and used for therapeutic and/or diagnostic purposes. The chelants are of the formula: ##STR1## wherein n, m, R, R.sup.1, R.sup.2 and L are defined in the specification.

REFERENCES:
patent: 5099069 (1992-03-01), Gansow et al.
patent: 5101041 (1992-03-01), Troutner et al.
patent: 5208324 (1993-05-01), Klaveness et al.
D. E. Troutner et al., "Pentadentate amine phenol complexes of .sup.99m Tc," Chem. Nucl. Med. 585-593 (1990).
M. R. A. Pillai et al., Bioconjugate Chem. 2, 191-197 (1990).
M. R. A. Pillai et al., J. Nucl. Med., Proceed. of 36th Annual Meeting, No. 430, p. 832 (1989).
G. H. Searle et al., Aust. J. Chem. 32, 519-36 (1979).
R. J. Motekaitis et al., Inorg. Chem. 23, (3), 275-283 (1984).
C. H. Paik et al., J. of Radioanal Chem. l57, (2), 553-564 (1980).
C. John et al., J. Nucl. Med. 29, 814-815 (1988).
M. W. Brechbiel et al., Inorg. Chem. 25, (16), 2772-2781 (1986).
A. W. Addison et al., Inorg. Chimica Acta 147, 61-64 (1988).
F. Refosco et al., J. Chem. Soc. Dalton Trans. 611-615 (1988).
E. Chiotellis et al., Nucl. Med. Biol. 15, (2), 215-223 (1988).
M. R. A. Pillai et al., J. Nucl Med., Proceed. of 36th Annual Meeting, No. 430, p. 832 (1989).
John et al., J Nucl Med, Proceed of 36th Annual Meeting, No. 306, pp. 814-815 (1989).
Motekaitis et al., Inorg Chem. 23, (3), 275-283 (1984).
F. Refosco et al., J Chem Soc. Dalton Trans., 611-615 (1988).

Affiliated with

Also associated with

Rating

Triamine chelants, their derivatives, complexes and conjugates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Triamine chelants, their derivatives, complexes and conjugates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Triamine chelants, their derivatives, complexes and conjugates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1404637