Triamide-substituted heterobicyclic compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C546S277400, C546S278100

Reexamination Certificate

active

06949572

ABSTRACT:
The invention relates to triamide MTP/ApoB inhibitors of the formula 1wherein R1-R8are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.

REFERENCES:
patent: 4022900 (1977-05-01), Mathison
patent: 4397855 (1983-08-01), Sircar
patent: 5416009 (1995-05-01), Lazzeri et al.
patent: 5712279 (1998-01-01), Biller et al.
patent: 5731340 (1998-03-01), Bras et al.
patent: 5741804 (1998-04-01), Keenan et al.
patent: 5919795 (1999-07-01), Chang et al.
patent: 5968950 (1999-10-01), Quallich et al.
patent: 6066653 (2000-05-01), Gregg et al.
patent: 6121283 (2000-09-01), Chang et al.
patent: 6197798 (2001-03-01), Fink et al.
patent: 6235730 (2001-05-01), Sato et al.
patent: 6281228 (2001-08-01), Tino
patent: 6288234 (2001-09-01), Griffin
patent: 6337344 (2002-01-01), Defossa et al.
patent: 2002/0032238 (2002-03-01), Priepke et al.
patent: 19945594 (2001-03-01), None
patent: 0643057 (1995-03-01), None
patent: 1006122 (2000-06-01), None
patent: 1080724 (2001-03-01), None
patent: 1099701 (2001-05-01), None
patent: 1181954 (2002-02-01), None
patent: 0584446 (2002-06-01), None
patent: WO 9727979 (1997-08-01), None
patent: WO 9743257 (1997-11-01), None
patent: WO 0005201 (2000-02-01), None
patent: WO 0076971 (2000-12-01), None
patent: WO 0105762 (2001-01-01), None
patent: WO 0121604 (2001-03-01), None
patent: WO 0147898 (2001-07-01), None
patent: WO 0147899 (2001-07-01), None
patent: WO 0153260 (2001-07-01), None
patent: WO 0177077 (2001-10-01), None
patent: WO 0192241 (2001-12-01), None
patent: WO 0196327 (2001-12-01), None
patent: WO 0197810 (2001-12-01), None
patent: WO 0204403 (2002-01-01), None
patent: WO 0242291 (2002-05-01), None
patent: WO 0283658 (2002-10-01), None
Watterau, J.R., et al.,Science, “Absence of Microsomal Triglyceride Transfer Protein in Individuals with Abetalipoproteinemia”, vol. 258, (Nov. 6, 1992).
Watterau, J.R., et al.,Biochimica et Biophysica Acta, “Localization of Intracellular Triacyglycerol and Cholesteryl Ester Transfer Activity in Rat Tissues”, vol. 875 pp. 610-617 (1986).
Jundong Zhang, et al., Bioorganic & Medicinal Chemistry, “Identification of Inhibitors of Heparin-growth factor interactions from Combinatorial Libraries of Four-Component Condensation Reaction”, (2001), vol. 9 No. 4, p. 825-836.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Triamide-substituted heterobicyclic compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Triamide-substituted heterobicyclic compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Triamide-substituted heterobicyclic compounds will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3423482

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.