Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1990-08-27
1992-02-25
Shah, Mukund J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546 77, C07J 7500, C07J 7300
Patent
active
050915347
ABSTRACT:
A novel single-pot trialkylsilyl trifluoromethanesulfonate (R.sub.3 Si--OTf) mediated process produces derivatives of 4-aza 3-keto steroids at the .alpha.-methylenic carbon through electrophilic substitution. These derivatives are useful in the preparation, through elimination of the substituent on the .alpha.-methylene carbon, of .DELTA.-1 olefin 4-aza 3-keto steroids which are potent inhibitors of 5-.alpha. reductase.
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Abramson Newton L.
Anderson Kevin
Douglas Alan W.
Karady Sandor
King Anthony O. P.
Caruso Charles M.
Merck & Co. , Inc.
Nicholson William H.
North Robert J.
Shah Mukund J.
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