Triacetin as a penetration enhancer for transdermal delivery of

Details Triacetin as a penetration enhancer for transdermal delivery of Triacetin as a penetration enhancer for transdermal delivery of

1995-04-26

1997-02-11

Phelan, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424449, 514946, A61F 1302

Patent

active

056018398

ABSTRACT:
A composition and method for enhancing transdermal penetration of a basic drug are described. The composition comprises a matrix patch comprising an effective amount of a basic drug, preferably having a pK.sub.a of about 8.0 or greater, an effective amount of penetration enhancer consisting essentially of triacetin, and a polymer later preferably comprising a pressure-sensitive adhesive. A preferred basic drug is oxybutynin and acid addition salts thereof. The method for enhancing transdermal penetration comprises applying the matrix patch to a selected area of skin.

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