Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-05-02
1998-06-16
Russel, Jeffrey E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 17, 514 18, 530329, 530330, 530331, A61K 3806, A61K 3807, A61K 3808, C07K 706
Patent
active
057670838
ABSTRACT:
The present invention discloses novel peptides utilized to treat patients suffering from depression. These novel peptides are modifications of the tripeptide hormone MIF, including modification of amino terminus residues, carboxyl terminus residues and internal residues, including addition and substitution of amino acid residues and modification of the peptide bonds and functional side groups of respective amino acid residues. The tri-, tetra-, penta-, peptides and polypeptides of the present invention may be utilized alone or in combination to treat patients suffering from depression.
REFERENCES:
patent: 3708593 (1973-01-01), Plotnikoff et al.
patent: 3795738 (1974-03-01), Plotnikoff et al.
patent: 3821188 (1974-06-01), McKinley et al.
patent: 3931184 (1976-01-01), Lex
patent: 4018912 (1977-04-01), Failli et al.
patent: 4278595 (1981-07-01), Cort
patent: 4610817 (1986-09-01), Albrecht et al.
patent: 5589460 (1996-12-01), Abajian et al.
Kastin, et al., 1984, Tyr-MIF-1 and MIF-1 are Active in the Water Wheel Test for Antidepressant Drugs, Pharmacology Biochem & Behavior, 21: 767-771.
Kastin, et al., 1985, Tyr-MIF-1, Identified in Brain Tissue, and Its Analogs are Active in Two Models of Antinociception, Pharamacology Biochem & Behavior, 23: 1045-1049.
Horvath, et al., 1989, Isolation of Typrosine-Melanocyte-Stimulating Hormone Release-Inhibiting Factor 1 from Bovine Brain Tissue, Journ. Biological Chem., 264:2175-2179.
Banks, et al., 1986, Carrier-Mediated Transport of Enkephalins and N-Tyr-MIF-1 Across Blood Brain Barrier, Am. J. Physiol. (Endorinol. Metab. 14): E477-E482.
Pulvirenti & Kastin, 1988, Blockade of Brain Dopamine Receptors Antagonizes the Anti-Immobility Effect of MIF-1 and Tyr-MIF-1 in Rats, European J. of Pharmacology, 151: 289-292.
Hayashhi, et al., 1983, Tyr-MIF-1 Affects Passive Avoidance Behavior but not Motor Activity in Rats, Pharm Research Bulletin, 11: 659-662.
Jaquenoud et R.A. Boissonnas, 1961, Synthese de la Ileu.sup.8 -oxytocine,et de la Val.sup.8 -oxytocine deux analogues de l'oxytocine modifies dans la chaine laterale, Helvetic Chimica Acta 44:113-122.
Deslauriers, et al., 1973, Intramolecular Motion in Peptides Determined by .sup.13 CNMR: A Spin-Lattice Relaxation Time Study on MSH-Release-Inhibiting Factor, FEBS Letters 37:27-32.
Studer, et al., 1960, Synthetic Work Related to Arginine-Vasopressin, J. Amer. Chem. Soc., 82:1499-1501.
Felix. et al., 1977, Synthesis Biological Activity, and Tritiation of L-3, 4-Dehydroproline-Containing Peptides, Int. J. Peptide Protein Res. 10:299-310.
Reissmann, 1988, Peptide Inhibitors of the Angiotensin Converting Enzyme with Nonproteinogenic Amino Acids, Collection Czechoslovak Chem Commun. 53:2591-2598.
Celis, 1972, Structure-Activity Studies of MSH-Release-Inhibiting Hormone, FEBS Letters 27:327-330.
Celis, et al., 1971, Regulation of Formation and Proposed Structure of the Factor Inhibiting the Release of Melanocyte-Stimulating Hormone, Proc. Natl. Acad. Sci. USA 68 (7): 1428-1433.
Nair, et al., 1971, Isolation Structure of Hypothalamic MSH Release-Inhibiting Hormone, Biochem Biophys. Reasearch Commun., 43 (6): 1376-1381.
Hayashi, et al., 1984, Some Analogs of Tyr-MIF-1 Affect Passive Avoidance Behavior but not Motor Activity in Rats, Pharmacology Biochem & Behavior, 21: 809-812.
Abajian Henry B.
Hlavka Joseph J.
Noble John F.
Innapharma, Inc.
Russel Jeffrey E.
LandOfFree
Tri-, tetra-, penta-, and polypeptides and their therapeutic use does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Tri-, tetra-, penta-, and polypeptides and their therapeutic use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tri-, tetra-, penta-, and polypeptides and their therapeutic use will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1726108