Tri-, Tetra-, Penta-, and polypeptides and their therapeutic use

Details Tri-, Tetra-, Penta-, and polypeptides and their therapeutic use Tri-, Tetra-, Penta-, and polypeptides and their therapeutic use

1997-11-04

2000-07-25

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

6 to 7 amino acid residues in defined sequence

514 17, 514 18, 530330, A61K 3807, A61K 3808, C07K 5107, C07K 706

Patent

active

060937971

ABSTRACT:
The present invention discloses novel peptides utilized to treat patients suffering from depression. These novel peptides are modifications of the tripeptide hormone MIF, including modification of amino terminus residues, carboxyl terminus residues and internal residues, including addition and substitution of amino acid residues and modification of the peptide bonds and functional side groups of respective amino acid residues. The tri-, tetra-, penta-, peptides and polypeptides of the present invention may be utilized alone or in combination to treat patients suffering from depression.

REFERENCES:
patent: 5589460 (1996-12-01), Abajian et al.
patent: 5767083 (1998-06-01), Abajian et al.
Hlavka et al. INN 00835--Antidepressant. Drugs of the Future. vol. 22, No. 12, pp. 1314-1318, 1997.

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