Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-06-07
1997-04-22
Chang, Ceila
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514252, 514255, 514256, 514277, 514332, 514340, 514367, 514383, 514374, 514394, 514427, 514438, 514544, 544242, 544335, 546266, 546339, 5462691, 5462701, 5462717, 5462724, 5462711, 5462697, 5462714, 5462734, 5462727, 5462781, 5462884, 5462811, 5462834, 5462841, 5482686, 5482678, 548179, 548239, 5483101, 5483411, 548562, 549 78, 560104, A61K 3144, C07D40510, C07D40910, C07D21304
Patent
active
056229771
ABSTRACT:
Compounds of the general formula (1) ##STR1## are described wherein Y is halogen or --OR.sup.1, where R.sup.1 is a substituted or unsubstituted alkyl; X is --O--, --S-- or --N(R.sup.8)--, where R.sup.8 is hydrogen or alkyl; R.sup.2 is substituted or unsubstituted alkyl, alkenyl, cycloalkyl or cycloalkenyl; R.sup.3 is hydrogen, halogen or --OR.sup.9, where R.sup.9 is hydrogen or substituted or unsubstituted alkyl, alkenyl, alkoxyalkyl, or alkanoyl, or formyl, carboxamido or thiocarboxamido; R.sup.4 and R.sup.5, which may be the same or different, are each --(CH.sub.2).sub.n Ar, where Ar is a monocyclic or bicyclic aryl group or monocyclic or bicyclic heteroaryl and n is integer of 0 to 3; R.sup.6 is hydrogen or substituted or unsubstituted alkyl; R.sup.7 is hydrogen or substituted or unsubstituted alkyl; and the salts, solvates, hydrates and N-oxides thereof. Compounds according to the invention are potent, selective and orally active PDE IV inhibitors and are useful in the prophylaxis and treatment of asthma and other diseases.
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Alexander Rikki P.
Boyd Ewan C.
Head John C.
Warrellow Graham J.
Celltech Therapeutics Limited
Chang Ceila
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