Tri-phenyl alkane derivatives and their oestrogenic, anti-oestro

Details Tri-phenyl alkane derivatives and their oestrogenic, anti-oestro Tri-phenyl alkane derivatives and their oestrogenic, anti-oestro

1989-10-12

1991-02-26

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548575, 564324, 514651, A61K 3140, C07D20708

Patent

active

049962256

ABSTRACT:
##STR1## wherein n is 0 to 4, R.sub.1 and R.sub.2, which can be the same or different, are H or OH; R.sub.3 is --O--(CH.sub.2).sub.m --CH.sub.2 --NR.sub.6 R.sub.7 wherein m is 1 or 2, R.sub.6 and R.sub.7, which can be the same or different, are H or an alkyl group of 1 to 4 carbon atoms, or --NR.sub.6 R.sub.7 can form a pyrrolidinyl group; and R.sub.4 is halogen, and their non-toxic pharmaceutically acceptable salts and phenolic esters of aliphatic or aromatic carboxylic acids, acid anhydrides or acid chlorides thereof are disclosed. These compounds exhibit valuable pharmacological properties as estrogenic, anti-estrogenic, and progestanic agents. They show activity against oestrogen-dependent tumors.

REFERENCES:
patent: 2914563 (1959-11-01), Allen
patent: 3288806 (1966-11-01), De Wald
patent: 4307111 (1981-12-01), Crawley

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