Tri-heterocyclic compounds and a pharmaceutical comprising...

Details Tri-heterocyclic compounds and a pharmaceutical comprising... Tri-heterocyclic compounds and a pharmaceutical comprising...

2005-09-07

2008-12-02

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S249000, C544S250000, C544S252000

Reexamination Certificate

active

07459459

ABSTRACT:
Tri-heterocyclic compound of formula (I)wherein each of W, X and Y is carbon or nitrogen; each of U and Z is CR2, NR13, nitrogen, oxygen, sulfur etc.; A ring is carbocyclic ring, heterocyclic ring; R1is alkyl, alkenyl, alkynyl, NR4R5, OR6etc.; R3is carbocyclic ring, heterocyclic ring;and a pharmaceutically acceptable salt thereof, a process for the preparation thereof, a pharmaceutical comprising them as an active ingredient.A compound of formula (I) is useful, in order to possess corticotropin releasing factor receptor antagonistic activity, for the prevention and/or treatment of depression, anxiety, eating disorder, posttraumatic stress disorder, peptic ulcer, irritable bowl syndrome, Alzheimer's disease, drug addiction or alcohol dependence syndrome etc.

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