Tri-aza macrocycles and processes for their preparation

Details Tri-aza macrocycles and processes for their preparation Tri-aza macrocycles and processes for their preparation

1992-03-31

1993-09-21

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540474, C07D25502, A61K 31395

Patent

active

052470776

ABSTRACT:
##STR1## Tri-aza macrocycles of formula (I), wherein m and n, which may be the same or different, is each zero or an integer 1, 2, or 3; p is zero or an integer 1 or 2; q is zero or an integer from 1 to 6 inclusive; R.sup.1, R.sup.2 and R.sup.3, which may be the same or different, is each a hydrogen atom or a group --CO.sub.2 H or --P(O)(XH)R.sup.4 (where X is an oxygen or sulpher atom and R.sup.4 is a hydrogen atom or an alkyl or alkoxy group), with the proviso that at least one of R.sup.1, R.sup.2 and R.sup.3 is a --P(O)(XH)R.sup.4 group; L is a covalent bond or a linker group; Z is a hydrogen atom or a reactive functional group; and metal complexes and/or salts thereof; are described together with processes for their preparation and compositions containing them. The compounds are useful as imaging agents, and in the treatment of abnormal cell disorders, such as in the treatment of tumours, and may be coupled to other molecules, such as proteins, for use in diagnosis and therapy.

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