Tri-aza macrocycles and metal complexes thereof

Details Tri-aza macrocycles and metal complexes thereof Tri-aza macrocycles and metal complexes thereof

1993-06-21

1996-01-16

Bond, Robert T.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303911, 5303913, 540465, 540474, 4241791, C07K 1600, A61K 39395, A61K 4722, A61K 4716

Patent

active

054848938

ABSTRACT:
Ti-aza macrocycles of formula (1), wherein m and n, which may be the same or different, is each zero or an integer 1, 2, or 3; p is zero or an integer 1 or 2; q is zero or an integer from 1 to 6 inclusive; R.sup.1, R.sup.2 and R.sup.3, which may be the same or different, is each a hydrogen atom or an alkyl, alkoxyalkyl, --CO.sub.2 H, --SO.sub.3 H, PO.sub.3 H.sub.2 or aryl group; L is a covalent bond or linker group; Z is a hydrogen atom or a reactive functional group, with the proviso that when L is a covalent bond Z is a reactive functional group; and metal complexes and/or salts thereof are described together with processes for their preparation and compositions containing them. The compounds are useful for imaging and in the treatment of abnormal cell disorders, such as in the treatment of tumours, and are particularly suitable for coupling to other molecules such as proteins for use in diagnosis and therapy.

REFERENCES:
patent: 4174319 (1979-11-01), Kobuke
patent: 4174428 (1979-11-01), Tabushi et al.
patent: 4432907 (1984-02-01), Wieder et al.
patent: 4472509 (1984-09-01), Gansow et al.
patent: 4659839 (1987-04-01), Nicolotti et al.
patent: 4671958 (1987-06-01), Rodwell et al.
patent: 4678667 (1987-07-01), Meares et al.
patent: 4877600 (1989-10-01), Bonnemain et al.
patent: 4885363 (1989-12-01), Tweedle et al.
patent: 5049667 (1991-09-01), Schaefer et al.
patent: 5053503 (1991-10-01), Dean et al.
patent: 5087696 (1992-02-01), Parker et al.
patent: 5271927 (1993-12-01), Parker et al.
Khaw et al., Science, 209, 295 (1980).
Krejcarek et al., Biochem. Biophys. Res. Comm., 77, 581 (1977).
Childs, R. L. and Hnatowich, D. J., J. Nuc. Med., 26, 293 (1985).
Stetter, H. et al., Angew. Chem. Int. Ed. Engl., 15, 686 (1976).
Loncin et al., Inorg. Chem., 25, 2646 (1986).
Moi et al., J. Am. Chem. Soc., 110, 6266 (1988).
Tweedle, M. F. et al., J. Nuc. Med., 28, 705 (1987).
Goodwin, C. H. et al., J. Nuc. Med., 27, 959 (1986).
Paik, C. H. et al., J. Nuc. Med., 28, 572 (1987).
Paik, C. H. et al., J. Nuc. Med., 29, 889 (1988).
Haseman, C. F. et al., Eur. J. Nuc. Med., 12, 455 (1986).
Parker et al., Pure & Appl. Chem., vol. 61, No. 9, 1637-1641 (1989).
Craig et al., J. Chem. Soc. Commun. (1989), pp. 794-796.
Cox et al., J. Chem. Soc. Chem. Commun. (1989), pp. 797-798.
Paik et al., J. Nucl. Sci., vol. 30, No. 10, pp. 1693-1701 (Oct. 1989).
Paik et al., Nucl. Med. Biol., vol. 16, No. 5, pp. 475-481 (1989).
Deshpande et al., Nucl. Med. Biol., vol. 16, No. 6, pp. 587-597 (1989).
Deshpande et al., The Journal of Nuclear Medicine, "Copper-67-Labeled Monoclonal Antibody Lym-1, A Potential Radiopharmaceutical for Cancer Therapy: Labeling and Biodistribution in RAJI Tumored Mice", vol. 29, No. 2, pp. 217-225 (Feb. 1988).
Franz, J. et al., Abstract from Journal of Nuclear Medicine, Abstract No. 553, vol. 26, No. 5 (May 1985).
Franz et al., Poster exhibited at 32nd Annual Meeting of the Society of Nuclear Medicine prior to May 1985.
Meares, Claude F., Protein Tailoring for Food and Medicine Uses, edited by R. E. Feeny et al., "Attaching Metal Ions to Antibodies", pp. 339-352 (1986).
Meares et al., Int. J. Cancer Suppl., 2, 99-102 (1988).
Meares et al., Br. J. Cancer, 62, 21-26 (1990).
Gansow et al., ACS Symposium Series, No. 241, "Generator Produced Bi-212" (1984).
Moi et al., Anal. Biochem., 148, 249-253 (1985).

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