Tri- and tetra-substituted-oxetanes and tetrahydrofurans and int

Details Tri- and tetra-substituted-oxetanes and tetrahydrofurans and int Tri- and tetra-substituted-oxetanes and tetrahydrofurans and int

1990-05-11

1991-08-13

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514252, 514253, 544262, 544364, 544366, 544369, 544370, A61K 31495, C07D40714

Patent

active

050396765

ABSTRACT:
This invention relates to tri- and tetra-substituted-oxetanes, e.g. (.+-.)-cis- and (.+-.)-trans-2-[(4-(4-isopropylpiperazin-1-yl)phenoxy)methyl]-4-(2,4-dihal ophenyl)-4-[1H-1,2,4-triazol-1-yl)-methyl]oxetane and tri- and tetra-substituted-tetrahydrofurans, e.g. (.+-.)-cis- and (.+-.)-trans-1-[4-[[2-(2,4-dihalophenyl)tetrahydro-2-[(1H-azol-1-yl)methyl ]-5-furanylmethoxy]phenyl]-4-yl-1-substituted piperazine-3-one and related derivatives which exhibit antifungal and antiallergy activities, pharmaceutical composition thereof, methods of their use in treating or preventing susceptible fungal infections and allergic reactions in a host including warm-blooded animals such as humans.

REFERENCES:
patent: 4518415 (1985-05-01), Marchington et al.
patent: 4618616 (1986-10-01), Richardson et al.
patent: 4634466 (1987-01-01), Noon et al.
patent: 4636247 (1987-01-01), Clouph et al.
Greiner et al., Chem Abst. vol. 108-217777s (1988).

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