Treatments for the control of schistosomiasis

Details Treatments for the control of schistosomiasis Treatments for the control of schistosomiasis

2011-03-22

2011-03-22

Anderson, James D (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S364000, C514S741000, C514S742000

Reexamination Certificate

active

07910574

ABSTRACT:
A method for controlling schistosome parasites in a mammal comprising delivering an effective amount of an agent for silencing TGR activity in the parasites.

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patent: 2006/0287396 (2006-12-01), Stevens et al.
Definition of “silencing”, Merriam-Webster's Medical Desk Dictionary at Merriam-Webster Online, 2005, downloaded from “http://www.merriam-webster.com/medical/silence”, p. 1 of 1.
Alger et al., Molecular & Biochemical Parasitology, 2002, vol. 121, pp. 129-139.
Cenas et al., “Interactions of Nitroaromatic Compounds with the Mammalian Selenoprotein Thioredoxin Reductase and the Relation to Induction of Apoptosis in Human Cancer Cells,” Journal of Biological Chemistry, vol. 281 (9), pp. 5593-5603 (Mar. 3, 2006).
Cerecetto et al., “Pharmacological Properties of Furoxans and Benzofuroxans: Recent Developments,” Mini-Reviews in MEdicial Chemistry, vol. 5 (1), pp. 57-71 (Jan. 2005).
Kuntz et al., “Thioredoxin Glutathione Reductase from Shistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target,” PLoS Medicine, vol. 4(6), pp. 1071-1086 (Jun. 2007).

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