Treatments for Flaviviridae virus infection

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C514S042000, C514S043000, C514S052000

Reexamination Certificate

active

07816339

ABSTRACT:
The present invention provides methods for treating infections, in a host, by viruses belonging to the Flaviviridae family, such as HCV, comprising administering an Ara-C homologue to the host.

REFERENCES:
patent: 3853845 (1974-12-01), Rousseau et al.
patent: 4542021 (1985-09-01), Kodama et al.
patent: 4659825 (1987-04-01), Holy et al.
patent: 4812560 (1989-03-01), Terada et al.
patent: 4879214 (1989-11-01), Kornher et al.
patent: 4927966 (1990-05-01), Kalman
patent: 5010103 (1991-04-01), Kalman
patent: 5049663 (1991-09-01), Terada et al.
patent: 5051498 (1991-09-01), Kalman
patent: 5512298 (1996-04-01), Aoki et al.
patent: 5646269 (1997-07-01), Matteucci et al.
patent: 5807876 (1998-09-01), Armistead et al.
patent: 5886162 (1999-03-01), Kalman
patent: 5889015 (1999-03-01), Sequeira et al.
patent: 6147058 (2000-11-01), Yoshimura et al.
patent: 6277830 (2001-08-01), Ganguly et al.
patent: 6312662 (2001-11-01), Erion et al.
patent: 6316462 (2001-11-01), Bishop et al.
patent: 6346379 (2002-02-01), Gelfand et al.
patent: 6472373 (2002-10-01), Albrecht
patent: 6545007 (2003-04-01), Sommadossi et al.
patent: 6566344 (2003-05-01), Gosselin et al.
patent: 6599914 (2003-07-01), Schleimer et al.
patent: 7524831 (2009-04-01), Malcolm et al.
patent: 2002/0151536 (2002-10-01), Davis et al.
patent: 2002/0198171 (2002-12-01), Schinazi et al.
patent: 2003/0203872 (2003-10-01), Secrist, III et al.
patent: 2003/0225029 (2003-12-01), Stuyver
patent: 2003/0235582 (2003-12-01), Singh et al.
patent: 2004/0110718 (2004-06-01), Devos et al.
patent: 2004/0265307 (2004-12-01), Singh et al.
patent: 0239015 (1991-10-01), None
patent: 0902035 (1999-03-01), None
patent: 0563697 (2001-07-01), None
patent: 1469577 (1977-04-01), None
patent: 52-065281 (1977-05-01), None
patent: 53-141284 (1978-12-01), None
patent: 55-049588 (1980-04-01), None
patent: 6-206822 (1994-07-01), None
patent: 6-206822 (2004-07-01), None
patent: WO 94/21658 (1994-09-01), None
patent: WO 95/29930 (1995-11-01), None
patent: WO 99/45016 (1999-09-01), None
patent: WO 00/52015 (2000-09-01), None
patent: WO 01/14345 (2001-03-01), None
patent: WO 01/32153 (2001-05-01), None
patent: WO 01/60315 (2001-08-01), None
patent: WO 01/90121 (2001-11-01), None
patent: WO 01/92282 (2001-12-01), None
patent: WO 01/96353 (2001-12-01), None
patent: WO 02/18404 (2002-03-01), None
patent: WO 02/053138 (2002-07-01), None
patent: WO02/53138 (2002-07-01), None
patent: WO 02/057287 (2002-07-01), None
patent: WO 02/057425 (2002-07-01), None
patent: WO 02/083126 (2002-10-01), None
patent: WO 02/094289 (2002-11-01), None
patent: WO 02/100415 (2002-12-01), None
patent: WO 03/026589 (2003-04-01), None
patent: WO 03/026675 (2003-04-01), None
patent: WO 03/051896 (2003-06-01), None
patent: WO 03/062255 (2003-07-01), None
patent: WO 03/062256 (2003-07-01), None
patent: WO 03/106621 (2003-12-01), None
patent: WO 2004/002422 (2004-01-01), None
patent: WO 2004/046331 (2004-06-01), None
Bartenschlager, In vitro models for hepatitis C. Virus Res. Jan 30, 2002;82(1-2):25-32.
Bartenschlager, Hepatitis C virus replicons: potential role for drug development. Nat Rev Drug Discov. Nov. 2002;1(11):911-6.
Beisler et al., Synthesis and antitumor activity of dihydro-5-azacytidine, a hydrolytically stable analogue of 5-azacytidine. J Med Chem. Jun. 1977;20(6):806-12.
Bellet et al., Hepatotoxicity of 5-azacytidine (NSC-102816) (a clinical and pathologic study). Neoplasma. 1973;20(3):303-9. No abstract available.
Brachwitz et al., 1-beta-D-Arabinofuranosylcytosine-5′-alkylphosphonophosphates and diphosphates: new orally active derivatives of ara-C. J Lipid Res. Jan. 1998;39(1):162-72.
Braess et al., Oral cytarabine ocfosfate in acute myeloid leukemia and non-Hodgkin's lymphoma—phase I/II studies and pharmacokinetics. Leukemia. Oct. 1998;12(10):1618-26.
Cadman et al., Clinical, biological, and biochemical effects of pyrazofurin. Cancer Res. Mar. 1978;38(3):682-8.
Debernardo et al., Synthesis of oxazinomycin (minimycin). J Org Chem. Jan. 7, 1977;42(1):109-12.
Diamond et al., Mycophenolic acid inhibits dengue virus infection by preventing replication of viral RNA, Virology 304:211-221 (2002).
Dix et al., Pyrazofurin metabolism, enzyme inhibition, and resistance in L5178Y cells, Cancer Res. Nov. 1979;39(11):4485-90.
Endresen et al., Folate supplementation during methotrexate treatment of patients with rheumatoid arthritis. An update and proposals for guidelines. Scand J Rheumatol. 2001;30(3):129-34.
Formann et al., Twice-weekly administration of peginterferon-alpha-2b improves viral kinetics in patients with chronic hepatitis C genotype 1. J Viral Hepat. Jul. 2003;10(4):271-6.
Hamada et al., Clinical pharmacokinetics of cytarabine formulations. Clin Pharmacokinet. 2002;41(10):705-18.
Harrap et al., Intracellular nucleotide pools and their significance in antimetabolite therapy. Antibiot Chemother. 1980;28:68-77.
Haspel et al., Temperature-sensitive mutants of mouse hepatitis virus produce a high incidence of demyelination. Proc Natl Acad Sci U S A. Aug. 1978;75(8):4033-6.
Higashigawa et al., Deoxyribonucleoside triphosphate pools and Ara-CTP levels in P388 murine leukemic cells treated with 1-B-D-arabinofuranosylcytosine-5′-stearylphosphate which is a newly synthesized derivative of 1-B-D-arabinofuranosylcytosine. Med Oncol Tumor Pharmacother. 1990;7(4):223-6.
Hirota et al., Regioselective BH3-hydride reduction of inosine derivatives, Tetrahedron Letters (2002) 43: 653-655.
Kerr et al., Highly water-soluble lipophilic prodrugs of the anti-HIV nucleoside analogue 2′,3′-dideoxycytidine and its 3′-fluoro derivative. J Med Chem. May 29, 1992;35(11):1996-2001.
Kerr et al., N4-(dialkylamino)methylene derivatives of 2′-deoxycytidine and arabinocytidine: physicochemical studies for potential prodrug applications. J Pharm Sci. Apr. 1994;83(4):582-6.
Kodama, K. et al., Antitumor activity and pharmacology of 1-beta-D-arabinofuranosylcytosine-5′-stearylphosphate: an orally active derivative of 1-beta-D-arabinofuranosylcytosine. Jpn J Cancer Res. Jul. 1989;80(7):679-85. Erratum in: Jpn J Cancer Res May 1990;81(5):544.
Kreutzer et al., Oxidized, deaminated cytosines are a source of C→ T transitions in vivo. Proc Natl Acad Sci U S A. Mar. 31, 1998;95(7):3578-82.
Krieger et al., Enhancement of hepatitis C virus RNA replication by cell culture-adaptive mutations. J Virol. May 2001;75(10):4614-24.
Kuhr et al., Treatment of patients with advanced chronic myelogenous leukemia with interferon-alpha-2b and continuous oral cytarabine ocfosfate (YNK01): a pilot study. Leuk Res. Jul. 2000;24(7):583-7.
P.Kong Thoo Lin et al., Synthesis and duplex stability of oligonucleotides containing cytosine-thymine analogues. Nucleic Acids Res. (1985) 17(24): 10373-10383.
Loeb et al., Lethal mutagenesis of HIV by mutagenic ribonucleoside analogs. AIDS Res Hum Retroviruses. Jan. 1, 2000;16(1):1-3.
Loeb et al., Lethal mutagenesis of HIV with mutagenic nucleoside analogs. Proc Natl Acad Sci U S A. Feb. 16, 1999;96(4):1492-7.
Maloisel F. et al., Results of a phase II trial of a combination of oral cytarabine ocfosfate (YNK01) and interferon alpha-2b for the treatment of chronic myelogenous leukemia patients in chronic phase. Leukemia. Apr. 2002;16(4):573-80.
Markland, W. et al., Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a comparison with ribavirin and demonstration of antiviral additivity with alpha interferon. Antimicrob Agents Chemother. Apr. 2000;44(4):859-66.
McCormick, Patrick J. et al., Changes in ribo- and deoxyribonucleoside triphosphate pools within the cell cycle of a synchronized mouse fibroblast cell line. Biochim Biophys Acta. Mar. 15, 1983;755(1):36-40.
Meyerhans, Andreas et al., Restriction and enhancement of human immunodeficiency virus type 1 replication by modulation of intracellular deoxynucleoside triphosphate pools. J Virol. Jan. 1994;68(1):535-40.
Moriyama, K. et al., Highly efficient random mutagenesis in transcription-reverse-transcription cycles by a hydrogen bond ambivalent nucleoside 5′-triphosphate

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