Treatment using prostoglandin and particulate formulations

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

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Details

424489, 424490, 424497, 424498, 514573, A61K 9127, A61K 9133, A61K 916

Patent

active

060306394

ABSTRACT:
Provided herein is a method of administering a free arachidonic acid metabolite to an animal, the method involving administration of the free metabolite and an endocytosable particle. This method can be used to treat animals afflicted with disorders characterized by cell activation and adhesion, inflammation or toxemia. Also provided is a method of treating a animal for such disorders by administration to the animals of a composition containing an anti-disorder effective amount of an endocytosable particle.

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Mizushima (1986) Drugs Exptl. Clin. Res. X 11(8) 681.
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Hoshi, et al., "Prostaglandin E, incorporated in lipid microspheres in the treatment of peripheral vascular diseases and diabetic neuropathy", Drugs Exptl. Clin. Res. 12(8):681, 1986.
Mizishuma, et al., "A multicenter double blind controlled study of lipo-pgge1, gpe1 incorporated in lipid microspheres, in peripheral vascular discease secondary to connective tissue disorders", J. rheymatol. 14:97 (1987).

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