Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-06-06
2006-06-06
Kemmerer, Elizabeth (Department: 1646)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S012200, C424S085100
Reexamination Certificate
active
07056882
ABSTRACT:
The invention is a treatment for increasing the bone mass or preventing bone loss in an individual afflicted with a bone disease which includes administering to the individual a morphogen in a therapeutically effective amount so as to maintain or stimulate bone formation.
REFERENCES:
patent: 4863732 (1989-09-01), Nathan et al.
patent: 4877864 (1989-10-01), Wang et al.
patent: 4925833 (1990-05-01), McNamara et al.
patent: 4968590 (1990-11-01), Kuberasampath et al.
patent: 4975526 (1990-12-01), Kuberasampath et al.
patent: 5011691 (1991-04-01), Oppermann et al.
patent: 5091513 (1992-02-01), Huston et al.
patent: 5106626 (1992-04-01), Parsons et al.
patent: 5106748 (1992-04-01), Wozney et al.
patent: 5108753 (1992-04-01), Kuberasampath et al.
patent: 5108922 (1992-04-01), Wang et al.
patent: 5116738 (1992-05-01), Wang et al.
patent: 5118667 (1992-06-01), Adams et al.
patent: 5141905 (1992-08-01), Rosen et al.
patent: 5154931 (1992-10-01), Kruger et al.
patent: 5187076 (1993-02-01), Wozney et al.
patent: 5208219 (1993-05-01), Ogawa et al.
patent: 5344654 (1994-09-01), Rueger et al.
patent: 5354557 (1994-10-01), Oppermann et al.
patent: 5393739 (1995-02-01), Bentz et al.
patent: 5453419 (1995-09-01), Murakami et al.
patent: 5496552 (1996-03-01), Kuberasampath et al.
patent: 5645591 (1997-07-01), Kuberasampath et al.
patent: 5674844 (1997-10-01), Kuberasampath et al.
patent: 5739107 (1998-04-01), Cohen et al.
patent: 5814604 (1998-09-01), Oppermann et al.
patent: 5840325 (1998-11-01), Kuberasampath et al.
patent: 5958441 (1999-09-01), Oppermann et al.
patent: 6013856 (2000-01-01), Tucker et al.
patent: 6027743 (2000-02-01), Khouri et al.
patent: 6110482 (2000-08-01), Khouri et al.
patent: 6281195 (2001-08-01), Rueger et al.
patent: 6333312 (2001-12-01), Kuberasampath et al.
patent: 6504079 (2003-01-01), Tucker et al.
patent: 6586388 (2003-07-01), Oppermann et al.
patent: 2020660 (1990-08-01), None
patent: 0128041 (1984-12-01), None
patent: 0148155 (1985-01-01), None
patent: 0416578 (1990-09-01), None
patent: 0436469 (1991-07-01), None
patent: 0512844 (1992-11-01), None
patent: 0514130 (1992-11-01), None
patent: 0514720 (1992-11-01), None
patent: WO 88/00205 (1988-01-01), None
patent: WO 89/09605 (1989-10-01), None
patent: WO 89/09787 (1989-10-01), None
patent: WO 89/09788 (1989-10-01), None
patent: WO 89/10409 (1989-11-01), None
patent: WO 90/01321 (1990-02-01), None
patent: WO 90/03733 (1990-04-01), None
patent: WO 91/05802 (1991-05-01), None
patent: WO 92/00382 (1992-01-01), None
patent: WO 9200432 (1992-01-01), None
patent: WO 92/02199 (1992-04-01), None
patent: WO 92/09697 (1992-06-01), None
patent: WO 92/13565 (1992-08-01), None
patent: WO 92/14481 (1992-09-01), None
patent: WO 92/15323 (1992-09-01), None
patent: WO 92/19262 (1992-11-01), None
patent: WO 92/20371 (1992-11-01), None
patent: WO 92/21355 (1992-12-01), None
patent: WO 92/21365 (1992-12-01), None
patent: WO 92/00432 (1993-01-01), None
patent: WO 93/00050 (1993-01-01), None
patent: WO 94/03600 (1994-02-01), None
Ngo et al., 1994, The Protein Folding Problem and Tertiary Structure Prediction, Birkhauer, Boston, pp. 491-495.
Wells, 1990, Biochemistry 29:8509-8517.
Kimmel, “Quantitative Histologic Changes in the Proximal Tibial Growth Cartilage of Aged Female Rats”, Cells and Materials Supplement 1, 11-18 (1991).
Luyten et al: Purification and Partial amino acid sequence of osteogenin, a protein initiating bone differentiation. J. Biol. Chem. 264:13377-13380 (1989).
Wozney et al., “Regulation of Chondrogenesis and Osteogenesis By The BMP Proteins”, Journ. of Cellular Biochemistry, Supplemental 16F, Abstract 026 (1992).
Basler et al., “Control of Cell Pattern in the Neural Tube: Regulation of Cell Differentiation by dorsalin-1, a Novel TGF.beta. Family Member”, (1993), 73 Cell, 687-702.
Behringer et al., “Abnormal sexual development in transgenic mice chronically expressing Mullerian inhibiting substance”, Nature, 345:167-170 (1990).
Caplan Arnold I., “Mesenchymal Stern Cells”, J. Orthop Res. 9:641-650 (1991).
Cate et al., “Isolation of the Bovine and Human Genes for Mullerian Inhibiting Substance and Expression of the Human Gene in Animal Cells”, Cell, 45:685-698 (1986).
Celeste et al., “Molecular Cloning of BMP-8: A Protein Present In Bovine Bone Which Is Highly Related To The BMP-5/6/7 Subfamily Of Osteoinductive Molecules”, Journ. of Cellular Biochemistry, Supplement 16F, Abstract 502 (1992).
Celeste et al. “Identification of transforming growth factor —beta. superfamily members present in bone-inductive protein purified from bovine bone”, Proc. Natl. Acad. Sci. 87:9843-9847 (1990).
Celeste et al., “Highly Purified Bovine Bone-Inductive Activity Contains Multiple Protein Species Related to BMP-2”, 54:105, Journal of Cellular Biochemistry, (1990).
Chen et al., “Bone Morphogentic Protein-2b Stimulation of Growth and Osteogenic Phenotypes in Rat Osteoblast-like Cells: Comparsion with TGF-.beta..sub.1 ”, J. Bone and Min, Res., 6:1893 (1991).
Chomcyzaski et al., “Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate-phenol-Chloroform Extraction”, Anal Biochem., 162:156-159 (1987).
D'Alessandro et al., “Purification, Characterization and Activity of Recombinant Human BMP-5”, 166:Q105 Journal of Cellular Biochemistry.
Dayoff Margaret O., “A Model of Evolutionary Change in Proteins”, Atlas of Protein Sequence and Structure 5:345-352, Suppl. 3 (1978).
Erben et al., “Histomorphometric Analysis of the Rat Proximal Tibal Metaphysis by Linear Scanning”, Scanning Microscopy, 4: (1990).
Green et al., “Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate”, Nature 347:391-394 (1990).
Ibbotson et al., “Contrasting Effects of Parathyroid Hormone and Insulin-like Growth Factor I in an Aged Ovariectomized Rat Model of Postmenopausal Osteoporsis”, J. Bone and Min. Res., 7:425-432 (1992).
Ibbotson et al., “Contrasting Effects of Parathyroid Hormone and Insulin-like Growth Factor I in an Aged Ovariectomized Rat Model of Postmenopausal Osteoporosis”, J. Bone and Min. Res., 7:425-432 (1992).
Israel et al., “Expression and Characterization of Bone Morphogenetic Protein-2 in Chinese Hamster Ovary Cells”, Growth Factors. vol. 7, 139-150 (1992).
Israel et al., “Expression of Recombinant BMP2 in Chinese Hamster Ovary Cells”, Journal of Cellular Biochemistry, 168:Q111.
Jee, Webster S.S., “The Aged Rat Model for Bone Biology Studies: Foreword,” Cells and Materials Supplement, 1: 1-2 (1991).
Katagiri et al., “The Non-Osteogenic Mouse Pluripotent Cell Line, C3H10T1/2, Is Inducted To Differentiate into Osteoblastic Cells By Recombinant Human Bone Morphogentic Protein-2,” Biochemical and Biophysical Research Communications, 172:295-299 (1990).
Lee, “Identification of a Novel Member (GF-1) of the Transforming Growth Factor-.beta. Superfamily”, Molecular Endrocinology, 90:1034-1040 (1990).
Lee, “Expression of growtn/differentiation factor 1 in the nervous system: Conservation of a bicistronic structure”, PNAS. 88:4250-4254 (1991).
Li et al., “Age-Related Changes of Cancellous and Cortical Bone Histomorphometry in Female Sprague-Dawley Rats,” Cell and Materials Supplement 1.25-35 (1991).
Lyons et al., “Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transfroming growth factor-.beta.-like genes coordinatley regulate aspects of embryonic development”, Genes & Development, 3:1657-1668 (1989).
Lyons et al., “Vgr-1. a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor .beta. gene superfamily”, PNAS, 86:4554-4558 (1989).
Malluche et al., “Renal bone disease 1990: An unmet challenge for the nephrologist” Kidney Intern., 38:193-211 (1990).
Mankin, “Ricke
Cohen Charles M.
Kuberasampath Thangavel
Oppermann Herrmann
Ozkaynak Engin
Pang Roy H. L.
Curis, Inc.
Fish & Neave IP Group Ropes & Gray LLP
LandOfFree
Treatment to prevent loss of and/or increase bone mass in... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Treatment to prevent loss of and/or increase bone mass in..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment to prevent loss of and/or increase bone mass in... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3698624