Drug – bio-affecting and body treating compositions – Topical body preparation containing solid synthetic organic... – Ophthalmic preparation
Reexamination Certificate
2011-07-26
2011-07-26
Azpuru, Carlos A (Department: 1615)
Drug, bio-affecting and body treating compositions
Topical body preparation containing solid synthetic organic...
Ophthalmic preparation
Reexamination Certificate
active
07985405
ABSTRACT:
A treatment solution used to prevent posterior capsular opacification is applied or introduced into the lens capsular bag before, during, or after cataract surgery. The treatment solution comprises an ion transport mechanism interference agent, which either alone or in combination with other treatment agents such as an osmotic stress agent and an agent to establish a suitable pH, selectively induces detachment and/or death of lens epithelial cells such that posterior capsular opacification is prevented. While the ion transport mechanism interference agent is capable of interfering with the cellular mechanisms and cell ion distribution of a broad range of cells, a concentration of agent is selected such that the treatment solution interferes selectively with the cellular mechanisms of lens epithelial cells while leaving other ocular cells substantially unharmed. The treatment solution selectively induces cellular death and/or detachment of lens epithelial cells while other ocular cells and tissue remain substantially unharmed and without lengthy preoperative pre-treatment.
REFERENCES:
patent: 5968824 (1999-10-01), Spruce et al.
patent: 32 41 765 (1984-05-01), None
patent: 39 06 311 (1990-08-01), None
patent: WO 90/09792 (1990-09-01), None
patent: WO 96/06863 (1996-03-01), None
patent: WO 00/37072 (2000-06-01), None
patent: WO 03/026744 (2003-04-01), None
patent: WO 2004/026288 (2004-04-01), None
patent: WO 2004/030653 (2004-04-01), None
Clark et al, “Inhibition of Posterior capsule opacification with an immunotoxin specific for lens epithelial cells:24 clinical resaults”, J Cataract Refract Surg., Dec. 1998, vol. 24, No. 12, pp. 1614-1620.
Patrick R. Cammarata et al., “Osmoregulatory Alterations in Taurine Uptake by Cultured Human and Bovine Lens Epithelial Cells,” Invest Ophthalmol Vis Sci., Feb. 2002, vol. 43, No. 2, pp. 425-433.
Donald S. Clark et al., “Inhibition of Posterior capsule opacification with an imunotoxin specific for lens epithelial cells: 24 month clinical results,” J Cataract Refract Surg., Dec. 1998, vol. 24, No. 12, pp. 1614-1620.
HS Chung et al., “Effect of mitomycin-C on posterior capsule opacification in rabbit eyes,” J Cataract Refract Surg., Oct. 2000, vol. 26, No. 10, pp. 1537-1542.
C.S. Liu et al., “A Study of Human Lens Cell Growth In Vitro. A Model for Posterior Capsule Opacification,” Invest Ophthalmol Vis Sci., Apr. 1996, vol. 37, No. 5, pp. 906-914.
W.R. Meacock et al., “Double-masked prospective ocular safety study of a lens epithelial cell antibody to prevent posterior capsule opacification,” J Cataract Refract Surg., May 2000, vol. 26, No. 5, pp. 716-721.
C.W. McLaughlin et al., “Timolol may inhibit aqueous humor secretion by cAMP-independent action on ciliary epithelial cells,” Am J Physiol Cell Physiol, Sep. 2001, vol. 281, No. 3, pp. C865-75.
O. Nishi, “Posterior capsule opacification. Part 1: Experimental investigations,” J Cataract Refract Surg., Jan. 1999, vol. 25, No. 1, pp. 106-117.
O. Nishi et al., “Removal of Lens Epithelial Cells by Dispersion With Enzymatic Treatment Followed by Aspiration,” Ophthalmic Surg., Aug. 1991, vol. 22, No. 8, pp. 444-450.
J.C. Parker, “In defense of cell volume?,” Am J Physiol., 1993, vol. 265, pp. C1191-1200.
J.C. Parker et al., “Effects of Ionic Strength on the Regulation of Na/H Exchange and K-CI Cotransport in Dog Red Blood Cells,” J Gen Physiol., Jun. 1995, vol. 105, No. 6, pp. 677-699.
J.M. Rakic et al., “Lens Epithelial Cell Proliferation in Human Posterior Capsule Opacification Specimens,” Exp Eye Res., 2000, vol. 71, No. 5, pp. 489-494.
D.H. Shin et al., “Decrease of Capusular Opacification with Adjunctive Mitomycin C in Combined Glaucoma and Cataract Surgery,” Ophthalmology, 1998, vol. 105, pp. 1222-1226.
E.D. Uebersax et al., “Survival of the Retinal Pigment Epithelium in vitro: Comparison of Freshly Isolated and Subcultured Cells,” Exp Eye Res, Mar. 2000, vol. 70, No. 3, p. 381-90.
L.M. Wagner et al., “Effect of protein kinase Cγ on gap junction disassembly in lens epithelial cells and retinal cells in culture,” Mol Vis, Mar. 2002, vol. 8, pp. 59-66.
J.J. Zhang et al., “Volume Regulation in the Bovine Lens and Cataract. The Involvement of Chloride Channels,” J Clin Invest., Feb. 1996, vol. 97, No. 4, pp. 971-978.
J.J. Zhang et al., “The Role of Chloride in the Lens of the Eye,” Exp Physiol., Mar. 1997, vol. 82, No. 2, pp. 245-259.
J.J. Zhang et al, “A new approach to measuring transepithelial potentials in the bovine lens reveals a chloride-dependent component,” Exp Physiol., Sep. 1994, vol. 79, No. 5, pp. 741-753.
J.J. Zhang, “Three different CI-channels in the bovine ciliary epithelium activated by hypotonic stress,” J Physiol., Mar. 1997, vol. 499 (Pt. 2), pp. 379-389.
E.K. Hoffman et al, “Membrane Mechanisms in Volume and pH Regulation in Vertebrate Cells,” Physiol. Rev. Apr. 1989, vol. 69, No. 2, pp. 315-382.
J.C. Parker, “Urea alters set point volume for K-CI cotransport Na-H exchange, and Ca-Na exchange in dog red blood cells,” Am. J. Physiol. Aug. 1993, vol. 265 (Pt. 1), pp. C447-52.
Sanderson et al., “pCMPS-Induced Changes in Lens Membrane Permeability and Transparency,” vol. 34, No. 8, 1993, pp. 2518-2525.
Use of Furosemide for the treatment of retardant formation of anterior chambers after glaucoma filtering surgery, Chinese Journal of Ocular Trauma and Occupational Eye Disease with Ophthalmic Surgery, Feb. 1999.
Azpuru Carlos A
McAndrews Held & Malloy Ltd.
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