Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1985-01-23
1988-03-29
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
514470, 514920, A61K 3578, A61K 3134
Patent
active
047342803
ABSTRACT:
The present invention relates to the treatment of PAF Acether-induced maladies. The treatment comprises the administration of a ginkgolide or a ginkgolide derivative. Ginkgolide B has been found to be the most effective. The ginkgolides may be introduced orally, intraveneously or by spray inhalation.
REFERENCES:
Chem. Abst. 77: 152375d, 1972.
J. Benveniste et al., "The Actions of PAF-Acether (Platelet-Activating Factor) on Guinea-Pig Isolated Heart Preparations", Br. J. Pharmac., 80, pp. 81-83, 1983.
K. Nakanishi, "The Ginkgolides", Pure and Applied Chemistry, 14, pp. 89-113, 1967.
M. Maruyama et al., "The Ginkgolides, Derivation of Partial Structures", Tetrahedron Letters No. 4, pp. 303-308, 1967.
K. Okaha et al., "Ginkgolides", J. Chem. Soc. (C), No. 74, pp. 2201-2206, 1967.
R. Bourgain et al., "A Continuous Registration Method in Experimental Arterial Thrombosis in the Rat", Thrombosis Research, vol. 4, pp. 599-607, 1974.
G. Camussi et al., "Platelet Activating Factor-Mediated Contraction of Rabbit Lung Strips: Pharmacologic Modulation", Immunopharmacology 6, pp. 87-96, 1983.
G. Basran et al. "Cromoglycate (DSCG) Inhibits Responses to Platelet-Activating Factor (PAF-Acether) in Man: An Alternative Mode of Action for DSCG in Asthma?", European Journal of Pharmacology, 86, pp. 143-144, 1983.
M. Sanchez-Crespo et al., "Vascular Actions of Synthetic PAF-Acether in the Rat: Evidence for a Platelet Independent Mechanism", Immunopharmacology 4, pp. 173-185, 1982.
R. Vargaftig, et al. "Non-Steroidal Anti-Inflammatory Drugs if Combined with Anti-Histamine and Anti-Serotonin Agents Interfere with the Bronchial and Platelet Effects of PAF-Acether", European Journal of Pharmacology, 82, pp. 121-130, 1982.
M. Braquet et al., "Leucocyte Leukotriene B.sub.4 Secretion Precedes Anergy in Burn-Injured Patients", The Lancet, No. 8409, Oct. 27, 1984, p. 976.
M. Braquet et al. "Leukocytic Functions in Burn-Injured Patients", Prostaglandins, 29, No. 5, p. 747, May 1985.
Brown Johnnie R.
Rollins John W.
Societe de Conseils de Recherches et d'Applications Scientifique
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