Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1997-05-30
2000-04-04
Duffy, Patricia A.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
514 12, 530350, A61K 3900, C07K 100
Patent
active
06045797&
ABSTRACT:
A method for treatment of a disease or condition in an organism characterized by an abnormal level of interaction between a BLM domain and its natural binding partner is described. The disease or condition may also be characterized by an abnormality in a signal transduction pathway, wherein the pathway contains a protein with a BLM domain. The method includes disrupting or promoting that interaction (or signal) in vivo. The method also involves inhibiting the activity of the complex formed between the BLM domain-containing protein and its natural binding partner. A method for diagnosis of such a disease or condition by detecting the level of such interaction as an indication of that disease or condition is also described. Also, a method for screening for an agent useful for treatment of such a disease or condition by assaying potential agents for the ability to disrupt or promote that interaction is described. The invention also features a peptide comprising, consisting or consisting essentially of a BLM domain.
REFERENCES:
patent: 3691016 (1972-09-01), Patel
patent: 3969287 (1976-07-01), Jaworek et al.
patent: 4195128 (1980-03-01), Hildebrand et al.
patent: 4215051 (1980-07-01), Schroeder et al.
patent: 4229537 (1980-10-01), Hodgins et al.
patent: 4247642 (1981-01-01), Hirohara et al.
patent: 4330440 (1982-05-01), Ayers et al.
patent: 4376110 (1983-03-01), David et al.
patent: 4946778 (1990-08-01), Ladner et al.
Margolis, B. et al, "The SH2 domain protein, GRB-7, is amplified, overexpressed, and in a tight complex with HER2 in breast cancer," Journal of Cellular Biochemistry Supplement , 18B: 1331-1340 (1994).
Aaronson, Science, 254:1146-1153 (1991).
Adelman et al., DNA, 2:183-193 (1983).
Bargmann et al., Nature, 319:226-230 (1986).
Bird, Science, 242:423-426 (1988).
Bitter et al., Methods in Enzymol., 153:516-544 (1987).
Colberre-Garapin et al., J. Mol. Biol., 150:1-14 (1981).
Cole et al., Monoclonal Antibodies and Cancer Therapy, Alan R. Liss, Inc., pp. 77-96 (1985).
Cote et al., Proc. Natl. Acad. Sci. USA, 80:2026-2030 (1983).
Domchek et al., Biochemistry, 31:9865-9870 (1992).
Fantl et al., Cell, 69:413-422 (1992).
Felder et al., Mol. Cell. Biol., 13:1449-1455 (1993).
Felgner and Ringold, Nature, 337:387-388 (1989).
Fingl and Woodbury, The Pharmacological Basis of Therapeutics, Ch. 1, pp. 1-46 (1975).
Fry et al., Protein Science, 2:1785-1797 (1993).
Hardie, Symp. Soc. Exp. Biol., 44:241-255 (1990).
Hunter, Cell, 64:249-270 (1991).
Huse et al., Science, 246:1275-1281 (1989).
Huston et al., Proc. Natl. Acad. Sci. USA, 85:5879-5883 (1988).
Inouye and Inouye, Nucleic Acids Res., 13:3101-3109 (1985).
Kozbor and Roder, Immunology Today, 4:72-79 (1983).
Koch et al., Science, 252:668-674 (1991).
Kohler and Milstein, Nature, 256:495-497 (1975).
Lam et al., Nature, 354:82-84 (1991).
Logan and Shenk, Proc. Natl. Acad. Sci. USA, 81:3655-3659 (1984).
Lowenstein et al., Cell, 70:431-442 (1992).
Lowy et al., Cell, 22:817-823 (1980).
Manser and Wood, Developmental Genetics, 11:49-64 (1990).
Marasco et al., Proc. Natl. Acad. Sci. USA, 90:7889-7893 (1993).
Margolis et al., Proc. Natl. Acad. Sci. USA, 89:8894-8898 (1992).
Margolis, Cell Growth & Differ., 3:73-80 (1992).
Millauer et al., Nature 367:576-579 (1994).
Morrison et al., Proc. Natl. Acad. Sci. USA, 81:6851-6855 (1984).
Mulligan and Berg, Proc. Natl. Acad. Sci. USA, 78:2072-2079 (1981).
Musacchio et al., TIBS, 18:342-348 (1993).
Neuberger et al., Nature, 312:604-608 (1984).
O'Hara et al., Proc. Natl. Acad. Sci. USA, 78:1527-1531 (1981).
Padhy et al., Cell, 28:865-871 (1982).
Pawson and Schlessinger, Current Biol., 13:434-442 (1993).
Pawson and Gish, Cell, 71:359-362 (1992).
Pendergrast et al., Cell, 75:175-185 (1993).
Posada and Cooper, Mol. Biol. Cell, 3:583-592 (1992).
Rotin et al., EMBO Journal, 11:559-597 (1992).
Ruther and Muller-Hill, EMBO Journal, 2:1791-1794 (1983).
Sadowski et al., Mol. Cell. Biol., 6:4396-4408 (1986).
Santerre et al., Gene, 30:147-156 (1984).
Schechter et al. Nature, 312:513-516 (1984).
Schlessinger and Ullrich, Neuron, 9(3):383-391 (1992).
Skolnik et al., Cell, 65:83-90 (1991).
Slamon et al., Science, 244:707-712 (1989).
Slamon et al., Science, 235:177-182 (1987).
Smith et al., J. Viol., 46:584-593 (1983).
Songyang et al., Cell, 72:767-778 (1993).
Stahl, Nature 332:269-272 (1988).
Stein et al., EMBO Journal, 13(6):1331-1340 (1994).
Szybalska and Szybalski, Proc. Natl. Acad. Sci. USA, 48:2026-2034 (1962).
Takeda et al., Nature, 314:452-454 (1985).
Ullrich and Schlessinger, Cell, 61:203-212 (1990).
Van Heeke and Schuster, J. Biol. Chem., 264:5503-5509 (1989).
Wigler et al., Proc. Natl. Acad. Sci. USA, 77:3567-3570 (1980).
Wigler et al., Cell, 11:223-232 (1977).
Yamamoto et al., Nature, 319:521-527 (1986).
Margolis Ben Lewis
Schlessinger Joseph
Duffy Patricia A.
New York University Medical Center
LandOfFree
Treatment or diagnosis of diseases or conditions associated with does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Treatment or diagnosis of diseases or conditions associated with, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment or diagnosis of diseases or conditions associated with will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-362272