Treatment of viscous mucous-associated diseases

Details Treatment of viscous mucous-associated diseases Treatment of viscous mucous-associated diseases

1995-05-05

1999-06-01

Bawa, Raj

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

424 46, 514958, 514851, A61K 912

Patent

active

059086114

ABSTRACT:
The present invention relates to therapeutic methods for treating diseases characterized by an accumulation of high molecular weight DNA in mucous, thereby contributing to the viscosity of the mucous. Such diseases include cystic fibrosis and chronic bronchitis. Treatment includes administration of weak organic acids to promote acidification of cells and consequently apoptosis-induced DNA fragmentation. The invention also relates to therapeutic apparatus for administering the acid compositions.

REFERENCES:
patent: 5292498 (1994-03-01), Boucher et al.
patent: 5512269 (1996-04-01), Molina y Vedia et al.
patent: 5635160 (1997-06-01), Stutts, III et al.
Barash et al., "Defective Acidication of Intracellular Organelles in Cystic Fibrosis", Nature, 352:70-73.
Barry et al., "Endonuclease Activation During Apoptosis: The Role of Cytosolic Ca2+ and pH", Biochem. Biophys. Res. Commun., 186:782-789 (1992).
Barry et al., "Etoposide-Induced Apoptosis in Human HL-60 Cells is Associated with Intracellular Acidification", Cancer Res., 53:2349-2357 (1993).
Caceres-Cortes et al., "Product of the Steel Locus Suppresses Apoptosis in Hemopoietic Cells," J. Biol. Chem., 269:12084-12091 (1994).
Elgavish et al., "Altered Sulfate Transport via Anion Exchange in CFPAC is Corrected by Retrovirus-Mediated CFTR Gene Transfer", Am. J. Physiol., 263:C176-186 (1992).
Karuri et al., "Selective Cellular Acidification and Toxicity of Weak Organic Acids in an Acidic Micro environment", Brit. J. Cancer, 68:1080-1087 (1993).
Keal, "Biochemistry and Rheology of Sputum in Asthma", Postgrad. Med. J., 47:171-177 (1971).
Knowles et al., "A Pilot Study of Aerosolized Amiloride for the Treatment of Lung Disease in Cystic Fibrosis", New Engl. J. Med., 322;1189-1194 (1990).
Li et al., "Apoptosis in an Interleukin-2-Dependent Cytotoxic T Lymphocyte Cell Line is Associated with Intracellular Acidification", J. Biol. Chem., 270:3203-3211 (1995).
Leiberman et al., "Measurement of Sputum Viscosity in a Cone-Plate Viscometer, I. Characteristics of Sputum Viscosity", Am. Rev. Respir. Dis., 97:654-661 (1968).
Leiberman et al., "Measurement of Sputum Viscosity in a Cone-Plate Viscometer, II. An Evaluation of Mucolytic Agents In Vitro", Am. Rev. Respir. Dis., 97:662-672 (1968).
Perez-Sala et al., "Intracellular Alkalinization Suppresses Lovastatin-Induced Apoptosis in HL-60 Cells Through the Inactivation of a pH-Dependent Endonuclease", J. Biol. Chem., 270:6235-6242 (1995).
Wyllie et al., "Cell Death: The Significance of Apoptosis", Int. Rev. Cytol., 68:251-306 (1980).
Moren, F. (1993). Aerosols in Medicine, 2nd edition. Elsevier, Netherlands, pp. 321-350.
Kohler, D. (1993). Aerosols in Medicine, 2nd edition. Elsevier, Netherlands, pp. 303-319.

Affiliated with

Also associated with

Rating

Treatment of viscous mucous-associated diseases does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Treatment of viscous mucous-associated diseases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment of viscous mucous-associated diseases will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-953445