Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1988-04-12
1991-12-31
Rollins, John W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
424 10, 514 50, 514 51, 514274, 514814, 514922, A61K 3170
Patent
active
050772805
ABSTRACT:
Treatments for viral infections are disclosed based on the finding that uridine can selectively protect and/or rescue uninfected cells, particularly human bone marrow progenitor cells, from the toxicity of pyrimidine nucleoside analogues during the treatment of retroviral diseases, such as AIDS, and that uridine phophorylase inhibitors are particularly effective in maintaining the necessary levels of uridine within such cells. A treatment for AIDS-type diseases is disclosed in which a pyrimidine nucleoside analogue and a uridine phosphorylase inhibitor are co-administered either simultaneously or sequentially to treat the viral infections and protect or rescue uninfected cells in the afflicted subject. This combination therapy also can be supplemented by direct administration of uridine.
REFERENCES:
patent: 3282921 (1966-11-01), Verheyden et al.
patent: 3687931 (1972-08-01), Verheyden et al.
patent: 3755295 (1973-08-01), Verheyden et al.
patent: 3775397 (1973-11-01), Etzold et al.
patent: 3817982 (1974-06-01), Verheyden et al.
patent: 4071680 (1978-01-01), Cook
patent: 4093715 (1978-06-01), Lin et al.
patent: 4128639 (1978-12-01), Lin et al.
patent: 4210638 (1980-07-01), Greer
patent: 4230698 (1980-10-01), Bobek et al.
patent: 4331662 (1982-05-01), Eckstein et al.
patent: 4604382 (1986-08-01), Lin et al.
patent: 4613604 (1986-09-01), Chu et al.
patent: 4681933 (1987-07-01), Chu et al.
patent: 4780453 (1988-10-01), Rideout et al.
patent: 4950466 (1990-08-01), Calabresi et al.
Balzarini et al., Biochemical and Biophysical Research Communications, vol. 140, No. 2, pp. 735-742, Oct. 30, 1986.
3'-Substituted 2',3'-Dideoxynucleoside Analogues as Potential Anti-HIV CHTLV-III/LAV) Agents, Herdewijn et al., J. Med. Chem. 30, 1270-1278.
Horwitz et al., "Nucleosides V. The Monomesylates . . . " vol. 29, The Rollin H. Stevens Memorial Library (1964), p. 2076.
Lin et al., "Synthesis and Biological Activity of Several Amino Analogues of Thymidine", vol. 21, No. 1, Journal of Medicinal Chemistry, pp. 109-112 (1977).
Niedzwicki et al., "Pyrimidine Acyclonucleosides . . . ", vol. 30, No. 15, Biochemical Pharmacology, pp. 2097-2101, (1981).
Lin et al., "Synthesis of . . . New Potent Uridine Phosphorylase Inhibitors with High Water Solubility", vol. 28, No. 971, Journal of Medicinal Chemistry (1985).
Sommadossi et al., "Toxicity of 3'-Azido-3'-Deoxythymidine and . . . ", Antimicrobial Agents and Chemotherapy, Mar. 1978, pp. 452-454.
Lin et al., "Antiviral Activity of 2',3'-Dideoxycytidin . . . ", vol. 36, No. 3, Biochemical Pharmacology, pp. 311-316, (1987).
Mitsuya et al., "3'-Azido-3'-Deoxythymidine (BW A 509U): . . . ", vol. 82, Proc. Natl. Acad. Sci., U.S.A., pp. 7096-7100 (1985).
Schinazi et al., "Selective In Vitro Inhibition of Human Immunodeficiency Virus . . . ", Abbott-UCLA Symposium, Apr. 1-6, 1987.
Ghazzouli et al., Paragraph from Antiviral Research, vol. 9, No. 1/2, Jan./Feb. 1988.
Niedzwicki et al., "5.varies.Benzylacyclouridine and 5-Benzyloxybenzylacyclouridine . . . ", vol. 31, No. 10, Biochemical Pharmacology, 1982, pp. 1857-1861.
Park et al., "Inhibition of Uridine Phosphorylase . . . ", vol. 35, No. 21, Biochemical Pharmacology, pp. 3853-3855 (1986).
Siegel et al., "Biological Activity of Two Novel Inhibitors . . . ", vol. 34, No. 7, Biochemical Pharmacology, pp. 1121-1124 (1985).
Darnowski et al., "Tissue-Specific Enhancement of Uridine Utilization . . . ", vol. 45, Cancer Research, pp. 5364-5368 (1985).
Monks et al., "Effect of 5-Benzylacyclouridine . . . by the Isolated Rat Liver", vol. 32, No. 13, Biochemical Pharmacology, pp. 2003-2009 (1983).
Chu et al., "Potentiation of 5-Fluoro-2'-Deoxyuridine Antineoplastic Activity . . . ", vol. 44, Cancer Research, pp. 1852-1856 (1984).
Lee et al., "Inhibition of Nucleoside Transport in Murine Lymphoma . . . ", vol. 44, Cancer Research, pp. 3744-3748 (1984).
Naguib et al., "New Analogues of Benzylacyclouridines . . . ", vol. 36, No. 13, Biochemical Pharmacology, pp. 2195-2201 (1987).
Falcone et al., "Effect of Benzylacyclouridine on
el Kouni Mahmoud H.
Sommadossi Jean-Pierre
Brown University Research Foundation
Engellenner Thomas J.
Geary III William C.
Loren Ralph A.
Rollins John W.
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