Treatment of vascular injury using vascular endothelial growth f

Details Treatment of vascular injury using vascular endothelial growth f Treatment of vascular injury using vascular endothelial growth f

1995-10-02

1998-11-03

Stanton, Brian R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

4353201, 435 694, 435 696, 435 698, 4351723, 435 912, 536 235, 536 2351, A01N 4304, A61K 3170, C12N 1563

Patent

active

058308792

ABSTRACT:
The present invention provides a method for inducing reendothelialization of the lining of an injured blood vessel comprising contacting the injured portion of the vessel with nucleic acid encoding an endothelial cell mitogen such as vascular endothelial growth factor (VEGF) operably linked to a promoter to result in expression of the mitogen when delivered to the cells at the site of vascular injury. The resulting reendothelialization of the injured blood vessel inhibits smooth muscle cell proliferation and consequently reduces restenosis. The methods of the present invention may be used to treat any blood vessel injury that results in denuding of the endothelial lining of the vessel wall, including, for example, those injuries resulting from balloon angioplasty and deployment of endovascular stents.

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