Treatment of vascular injury

Details Treatment of vascular injury Treatment of vascular injury

1992-07-16

1994-05-03

Kishore, G. S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

514 2, 514 21, 530350, 530399, 530402, A61K 3702

Patent

active

053086228

ABSTRACT:
Patients suffering vascular injury as a result of balloon catheterization or the like are treated with medicaments containing conjugates comprising a ligand, such as bFGF (or another FGF polypeptide), and a cytotoxic agent. The cytotoxic agent can be a ribosome-inactivating protein (RIP), such as saporin, which is attached to the ligand through a chemical bond or prepared as a recombinant DNA chimera. The medicament containing the conjugate is administered IV to patients after they have been treated for atherosclerosis in a manner which commonly results in vascular injury, particularly to the intima, and effectively prevents restenosis. The conjugate kills proliferating smooth muscle cells in the lumen of the blood vessels which surprisingly express large numbers of high-affinity bFGF receptors while not inhibiting the growth of endothelial cells.

REFERENCES:
patent: 4956455 (1990-09-01), Esch et al.
patent: 5084556 (1992-01-01), Brown
Lappi et al BBRC 160 #2, p. 917, 1989.
Circulation, Supplement III, vol. 82, No. 4, Oct. 1990; Ward Casscells, et al., "Smooth Muscle Proliferation in Vessel Injury is Inhibited by a Toxin-Fibroblast Growth Factor Conjugate".
Circulation Research, vol. 68, No. 1, Jan. 1991; V. Lindner, et al.; "Role of Basic Fibroblast Growth Factor in Vascular Lesion Formation".

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