Treatment of uterine contractility disorders with a nitric oxide

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 21, 514171, 514412, 514470, 514561, 514563, 514565, 514648, 514651, 514652, 514742, 514841, 514843, A61K 3104, A61K 3156, A61K 31195, A61K 31155

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active

059487623

ABSTRACT:
Dysmenorrhea, disfunctional uterine bleeding, preterm labor and postpartum labor in female mammals are treated by inhibiting uterine contractility by administering thereto a nitric oxide synthase substrate, a nitric oxide donor or both, optionally in combination with one or more of a prostaglandin inhibitor, a prostacyclin-mimetic, a progestin, an oxytocin antagonist or a .beta.-agonist in an amount effective to ameliorate the symptoms thereof; and inadequate menses treated and induction of abortion or stimulation of labor in a pregnant female is achieved by uterine contractility stimulation by administering thereto a nitric oxide inhibitor, either alone or optionally in a combination of progesterone antagonist, an oxytocin or-oxytocin analogue antagonist or a prostaglandin.

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