Treatment of upper respiratory conditions

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert

Reexamination Certificate

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C514S171000

Reexamination Certificate

active

07867508

ABSTRACT:
Provided are compositions and methods useful for the non-addictive treatment and prevention of upper respiratory conditions in man and animals, e.g., allergic, non-allergic and mixed rhinitis in man or pharyngitis and IAD in horses. Compositions of the invention comprise effective amounts of a suitable nasal decongestant; a suitable corticosteroid; and a suitable anticholinergic agent. The compositions and methods provided are especially useful for long term use in patients with mixed rhinitis and substantially reduce or eliminate the risk of rhinitis medicamentosa. The compositions and methods of treatment provided also eliminate the risk of adverse sequella seen from therapeutic regimens which employ systemic use of decongestants. The compositions provided can further comprise a suitable aromatic and/or a suitable antihistamine and can also comprise optional suitable antimicrobials, cytokine modulators, leukotriene antagonists, cromolyn sodium, or a suitable NDAID agent.

REFERENCES:
patent: 5698558 (1997-12-01), Gray
patent: 5889015 (1999-03-01), Sequeira et al.
patent: 6344210 (2002-02-01), Fust
patent: 6777441 (2004-08-01), Wang et al.
patent: 2002/0061281 (2002-05-01), Osbakken et al.
Black et al. (1980) “Rhinitis Medicamentosa” CMA Journal vol. 122; pp. 881-884.
William Storms (2007) “Allergic rhinitis-induced nasal congestion: its impact on sleep quality” Primary Care Respiratory Journal; 17(1); pp. 7-18.
Dr. James Thompson “Nasal Spray Addiction-Know the Facts and Avoid the Danger” My Allergy Network.com, (2008).

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