Treatment of type 2 diabetes mellitus

Details Treatment of type 2 diabetes mellitus Treatment of type 2 diabetes mellitus

1994-08-23

1998-02-10

Hutzell, Paula K.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

4241311, 4241391, 4241411, 4241451, 4241561, 514 12, 514866, A61K 39395, A61K 3800

Patent

active

057166196

ABSTRACT:
Antibody methods for blocking the effects of diabetes-associated peptide, or "amylin", a hormone found in the amyloid masses of Type 2 diabetics, are disclosed. This putative hormone has been discovered to function both to inhibit insulin secretion and to inhibit glycogen synthesis. Regulation is accomplished by blocking the binding of amylin or amylin agonists, including calcitonin gene related peptide (CGRP), or biologically active sub-peptides thereof. Inhibitors include antibodies directed to amylin and amylin agonist active sites. Other antagonists include anti-idiotype antibodies directed to antibodies directed to amylin.

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