Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds expression product or fragment thereof of...
Patent
1994-11-30
1998-10-20
Scheiner, Toni R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Binds expression product or fragment thereof of...
4241431, 5303877, 53038822, C07K 1630, C07K 1628
Patent
active
058243119
ABSTRACT:
A method of treating certain mammalian tumors with monoclonal antibodies is provided. Monoclonal antibodies specific to distinct epitopes of p185, the translation production of the neu oncongene, are provided, and these are then contacted with the tumor antigen under conditions which allow binding of the antibodies to a degree sufficient to inhibit tumor growth. The monoclonal antibodies act synergistically thus enhancing their anti-tumorigenic effect upon the tumor. An injectable composition for treating certain mammalian tumors with monoclonal antibodies and methods for diagnosing mammalian cancer tumors which express the protein p185 on the surface of the cells are also disclosed.
REFERENCES:
patent: 4443427 (1984-04-01), Reinnerz et al.
patent: 4444744 (1984-04-01), Goldenberg
patent: 4454106 (1984-06-01), Gansow et al.
patent: 4522918 (1985-06-01), Schlom et al.
Bargmann et al., "The neu Oncogene Encodes an Epidermal Growth Factor Receptor-related Protein", Nature vol. 319, pp. 226-230 (1986).
Bast et al., "Elimination of Malignant Clonogenic Cells from Human Bone Marrow Using Multiple Monoclonal Antibodies and Complement" Cancer Research 45: 499-503 (1985).
Bialy, H., "The Ripening Fruits of Receptor Biology" Biotechnology 5: 207 (1987).
Capone et al., "Relationship Between Antigen Density And Immunotherapeutic Response Elicited by Monoclonal Antibodies Against Solid Tumors" JCNI 72: 673-677 (1984).
Ceriani et al., "An Experimental Model for the Immunological Treatment of Breast Cancer" Proc. International Workshop on Molecular Antibodies 248-268 (1984).
Chu, "Potential Applications of Monoclonal Antibodies in Cancer Diagnosis and Therapy" Cancer Investigation 3(6): 565-584 (1985).
Dillman, "Monoclonal Antibodies for Treating Cancer" Annals of Internal Medicine 111: 592-603 (1989).
Drebin et al., "Monoclonal Antibodies Reactive with Distinct Domains of the neu Oncogene-encoded p185 Molecule Exert Synergistic Anti-tumor Effects in Vivo" Oncogene 2: 273-277 (1988).
Drebin et al., "Down-Modulation of an Oncogene Protein Product and Reversion of the Transformed Phenotype by Monoclonal Antibodies" Cell 41: 695-706 (1985).
Drebin et al., "Development of Monoclonal Antibodies Reactive with the Product of the Neu Oncogene " Symposium on Fundamental Cancer Research 38: 277-289 (1986).
Drebin et al., "Monoclonal Antibodies Identify a Cell-Surface Antigen Associated with an Activated Celular Oncogene" Nature 312: 545-548 (1984).
Drebin et al., "Monoclonal Antibodies Specific for the Neu Oncogene Product Directly Mediate Anti-Tumor Effects in Vivo" Oncogene 2: 387-394 (1988).
Drebin et al., "Inhibition of Tumor Growth by a Monoclonal Antibody Reactive with an Oncogene-Encoded Tumor Antigen" PNAS USA 83: 9129-9133 (1986).
Eisenberg et al., "The Helical Hydrophobic Moment: A Measure of The Amphiphilicity of a Helix" Nature 229: 371-374 (1982).
Fendly et al., "Characterization of Murine Monoclonal Antibodies Reactive to Either the Human Epidermal Growth Factor Receptor or HER2
eu Gene Product" Cancer Res. 50: 1550-1558 (1990).
Harris et al., "Therapeutic Antibodies--the Coming of Age" Tibtech 11: 42-44 (1993).
Herbert et al., "Dictionary of Immunology" Blackwell Sci. Publ. p. 120 (1971).
Herlyn et al., Journal of Immunology 134: 1300-1304 (1985).
Hird et al., "Genes & Cancer" Carney et al. Eds., Wiley, pp. 183-189 (1990).
Hung et al., "Molecular Cloning of the Neu Gene: Absence of Gross Structural Alteration in Oncogenic Alleles" PNAS USA 83: 261-264 (1986).
Olsson, L., "Human Monoclonal Antibodies in Experimental Cancer Research" JCNI 75: 397-403 (1985).
Osband et al., "Problems in the Investigational Study and Clinical Use of Cancer Immunotherapy" Immunology Today 11: 193-195 (1990).
Pepys, "Role of Complement in Induction of the Allergic Response" Nature New Biology 237: 157 (1972).
Rose et al., "Hydrophobicity of Amino Acid Residues In Globular Proteins" Science 229: 834-838 (1985).
Schlom "Monoclonal Antibodies: They're More and Less Than You Think" in Molecular Foundations of Oncology, Brode, Ed., Williams and Wilkens pp. 95-134 (1991).
Spiegelman et al., "Molecular Cloning of mRNA from 3T3 Adipocytes" J. Biol Chem. 258: 10083-10089 (1983).
Sugita et al., "Use of a Cocktail of Monoclonal Antibodies and Human Complement in Selective Killing of Acute Lymphocytic Leukemia Cells" Int. J. Cancer 37: 351-357 (1986).
Thiery et al., "Pathways and Mechanisms of Avian Trunk Neural Crest Cell Migration and Localization" Develop Biol. 93: 324-343 (1982).
Trojanowski et al, "A Comparison of Eight Different Chromogen Protocols for the Demonstration of Immunoreactive Neurofilaments or Glial Filaments in Rat Cerebellum Using the Peroxidase-Antiperoxidase Method and Monoclonal Antibodies" J. Histochem. Cytochem. 31: 1217-1223 (1983).
Waldmann, "Monoclonal Antibodies in Diagnosis and Therapy" Science 252: 1657-1662 (1991).
Wawrzynczak et al., "Strategies in Antibody Therapy of Cancer" Clin. Exp. Immuol. 82: 189-193 (1990).
Yung and Cudkowicz, "Abrogation of Resistance to Foreign Bone Marrow Grafts by Carageenans II. Studies with the Anti-Macrophage Agents" J. Immunology 119: 1310 (1977).
Drebin et al., "In Vivo and In Vitro Effects of Monoclonal Antibodies which Recognize a Cell Surface Oncogene Product" J. Cell Biochem. 0(9 Part A) p. 72 ( Abstract #0170) (1985).
Wada, T. et al., "Intermolecular Association of the p185.sup.neu Protein and EGF Receptor Modulates EGF Receptor Function" Cell 61: 1339-1347 (1990).
Qian et al., "p185.sup.c-neu and epidermal growth factor receptor associate into a structure composed of activated kinases" PNAS USA 89: 1330-1334 (1992).
Mattern et al., "Human Tumor Xenografts as Model for Drug Testing" Cancer and Metastasis Reviews 7: 263-284 (1988).
Waldmann, "The Interleukin-2 Receptor: A Target for Immunotherapy of Leukemia/Lymphoma" J. Cell. Biochem. Supp 18D #R008 p. 100 (1994).
Hynes et al., "Recombinant Single Chain Immunotoxins Specific for EGF & ERBB-2 Receptors Inhibit in Vivo and in Vitro Tumor Cell Growth" J. Cell. Biochem. Supp 18D: #Y208 p. 237 (1994).
Dougall et al., "Modulation of p185.sup.c-erb-2 Expression and Tumorigenic Growth by Anti-Receptor Monoclonal Antibodies" J. Cell. Biochem. Supp 18D #Y507 p. 252 (1994).
Houghton et al., "Monoclonal Antibodies: Potential Applications to the Treatment of Cancer" Seminars in Oncology 13: 165-179 (1986).
Bookman et al., "Immunotoxins Directed Against c-erbB2: Limited Activity Due to Poor Internalization" Third International Symposium on Immunotoxins p. 15 (1992).
Wright et al., "Expression of c-erbB-2 Oncoprotein: A Prognostic Indicator in Human Breast Cancer" Cancer Res. 49: 2087-2090 (1989).
Zee-Cheng and Cheng, "Screening and Evaluation of Anticancer Agents" Meth and Find. Exptl. Clin Pharmacol 10(2) 67-101 (1988).
Horak, Eva et al., "Radioimmunotherapy of Nude Mice Bearing a Human Her2/Neu Positive Tumor Utilizing the .alpha.-emitting Radionuclide-Conjugated Monoclonal Antibody .sup.212 Pb-Dota-Ae1" Abstract #Y 509 from Breast and Prostate Cancer II, p. 252.
Seaver, Genetic Engineering News vol.14:10,21, 1994.
Wawrzynczak et al., Clin Exp. Immunol.82; 189-193, 1990.
Dillman et al. J.Clinical Oncology 12:1497-1515 1994.
Drebin Jeffrey A.
Greene Mark I.
Scheiner Toni R.
Trustees of the University of Pennsylvania
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