Treatment of tumors with autologous LAK cells, interleukin-2 and

Details Treatment of tumors with autologous LAK cells, interleukin-2 and Treatment of tumors with autologous LAK cells, interleukin-2 and

1989-12-05

1991-03-26

Stone, Jacqueline

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using a micro-organism to make a protein or polypeptide

4352402, 424 93, 424534, 424 852, C12P 2100, C12N 506, A61K 4505

Patent

active

050028790

ABSTRACT:
Ornithine decarboxylase inhibitors when administered in conjunction with autologous LAK cells and interleukin-2 provide for an enhanced treatment of neoplastic disease states. This enhancement is provided by the ability of an ornithine decarboxylase inhibitor to reduce tumor load and to enhance interleukin-2 production in T helper cells.

REFERENCES:
patent: 4499072 (1985-02-01), Sunkara et al.
patent: 4690915 (1987-09-01), Rosenberg
Bowlin et al., Immunopharmacology 13(2) 1987, pp. 143-148.

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