Treatment of tumors with 5-radioiodo-2'-deoxyuridine

Details Treatment of tumors with 5-radioiodo-2'-deoxyuridine Treatment of tumors with 5-radioiodo-2'-deoxyuridine

1990-03-30

1991-12-31

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

600 4, A61K 4300

Patent

active

050770349

ABSTRACT:
A method for the treatment and diagnosis of tumors is disclosed. This method comprises the direct administration of an effective anti-tumor amount of a radiohalogenated pyrimidine nucleoside such as .sup.123 IUdR or .sup.125 IUdR to the affected site.

REFERENCES:
patent: 3261747 (1966-07-01), Commerford
patent: 4851520 (1989-07-01), Kassis et al.
Mercer et al., "Synthesis and Tumor Uptake of . . . Uracils", J. Med. Chem. vol. 30, No. 4, 1987 pp. 670-675.
Knol et al., "5-Brono-2'-Deoxyuridine Incorporation Into DNA . . . " J. Surg. Research, vol. 47, No. 3 Aug. 1989, pp. 112-116.
Mercer et al., "Synthesis and Tumor Uptake of 5-.sup.82 Br and 5-.sup.131 I Labellen . . . Uracils", J. Med. Chem., vol. 32, No. 6, 1989, pp. 1289-1294.

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