Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated to proteinaceous toxin or fragment thereof
Patent
1994-06-13
1998-03-17
Hutzell, Paula K.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated to proteinaceous toxin or fragment thereof
424832, 4241941, 42419511, 514 8, 514 12, 514 21, 5303917, 530394, 530380, 5303881, 5303882, 53038822, 5303877, 5303888, 530363, A61K 39395
Patent
active
057283834
ABSTRACT:
Potent and specific immunotoxins are prepared by conjugation of moieties binding to receptors on the surface of tumor cells to a mutant diphtheria toxin having A-chain translocation activity, but lacking membrane-binding activity. The immunotoxins are used to treat primary tumors of neurologic origin, metastatic tumors of small cell lung carcinoma or breast carcinoma origin, leptomeningeal leukemia and leptomeningeal carcinomatosis. The preferred route of administration of the immunotoxin is to a compartment of the body containing cerebrospinal fluid.
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Johnson Virginia
Youle Richard J.
Bakalyar Heather A.
Hutzell Paula K.
The United States of America as represented by the Secretary of
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