Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-03-29
1997-02-11
Burn, Brian M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 13, 514 14, 514 15, 514 16, 514 17, 514 21, A61K 3809
Patent
active
056020945
ABSTRACT:
Malignant gliomas are treated by modifying the eicosanoid biosynthetic pathway with reduction of the inhibitory effect of prostanoids on the cytotoxic activity of NK and LAK cells. Synthetic peptides, corresponding to shared sequences with phospholipase activating protein (PLAP), having the capacity to activate phospholipase A.sub.2 (PLA.sub.2), when administered in a delayed release delivery system, such as with agarose beads induce release of PGE.sub.2, with significant tumor necrosis. A tumor model comprising an air pouch in the dorsum of rats is utilized for effective evaluation of the treatment, with tumor growth, treatment and evaluation of tumors grown therein.
REFERENCES:
patent: 4014909 (1977-03-01), Torossion et al.
patent: 5527775 (1996-06-01), Shorr et al.
Biochem J. (1988)250: 125-32.
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