Treatment of tumor cells in vitro with neurotrophic factors and

Details Treatment of tumor cells in vitro with neurotrophic factors and Treatment of tumor cells in vitro with neurotrophic factors and

1992-08-27

1995-02-07

Draper, Garnette D.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

530399, 514 2, 514 8, 514 12, 4352401, 435243, 435244, 435245, A61K 3702, A61K 3736, C07H 1500

Patent

active

053875206

ABSTRACT:
Disclosed are methods and compositions for treating neuroblastoma cells. The methods include contacting the neuroblastoma cells with a neurotrophic factor and less than a lethal dose of an inhibitor of cell proliferation for about 1 to 15 days, and then maintaining the neuroblastoma cells in contact with the neurotrophic factor for an additional 1 to 15 days. The composition includes a neurotrophic factor such as the neurotropin, nerve growth factor, and an inhibitor of cell proliferation such as aphidicolin, thymidine, or hydroxyurea. Also disclosed are methods for inducing the remission or differentiation of, or eliminating, neuroblastoma cells.

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