Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-12-08
1991-01-01
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3140
Patent
active
049818678
ABSTRACT:
A method of treating tremor in mammals, comprising administering to a mammal susceptible to tremor an effective amount of a compound that depresses calcium current in thalamic neurons. Succinimides are particularly effective.
REFERENCES:
Sinton et al., "The Effectiveness of Different Isomers of Octanol as Blockers of Harmaline-Induced Tremor," European Journal of Physiology (1989) 414:31-16.
DeLong, "Possible Involvement of Central Pacemakers in Clinical Disorders of Movement," Fed. Proc. (1978) 37:2171-2175.
Coulter et al., "Specific Petit Mal Anticonvulsants Reduce Calcium Currents in Thalamic Neurons," Neuroscience Letters (1989) 98:74-78.
Coulter et al., "Calcium Currents in Rat Thalamocortical Relay Neurons: Kinetic Properties of the Transient, Low-Threshold Current," Journal of Physiology (1989) 414:587-604.
Coulter et al., "Characterization of Ethosuximide Reduction in Low-Threshold Calcium Current," Annals of Neurology (1989) 25:582-593.
Friedman Stanley J.
Neeley Richard L.
The Board of Trustees of the Leland Stanford Junior University
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