Treatment of thrombotic events

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 44, 424 9463, 424350, 424337, 424520, 530355, 530855, A01N 3718, A61K 3800, A61K 3848, C07K 100

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active

059770562

ABSTRACT:
A method for preventing the formation of platelet-rich clots or thrombus, and for deaggregating platelet-rich clots or thrombus, using hementin, a polypeptide derived from leech salivary glands. Hementin may be administered for this purpose in a pharmaceutically acceptable carrier or excipient, with or without additional anticoagulants such as hirudin, hirudin analogues, or an inhibitor of factor Xa.

REFERENCES:
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patent: 4832849 (1989-05-01), Cardin
Malinconico et al., "Fabrinogen degradation by hementin, a fibrinogenolytic anticoagulant from the salivary glands of the leech Haementeria ghilanii," J. Lab. Clin. Med., vol. 104, No. 5, (Nov. 1984).
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Yasuda et al., "Lysis of Plasminogen Activator-Resistant Platelet-Rich Coronary Artery Thrombus With Combined Bolus Injection of Recombinant Tissue-Type Plasminogen Activator and Antiplatelet GPIIb/IIIa Antibody," JACC, vol. 16, No. 7, 1728-35, (Dec. 1990).
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