Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-12-05
1997-07-08
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A16K 3134
Patent
active
056461801
ABSTRACT:
Methods and compositions for treating the central nervous system (CNS) effects of HIV, particularly AIDS related dementia.
REFERENCES:
M.E. Brewster and N. Bodor, "Redox Approaches to Drug Delivery to the Central Nervous System", in Bioavailability of Drugs to the Brain and the Blood-Brain Barrier, J. Frankenhiem and R.M. Brown, eds., Research Monograpph 120, pp. 169-201, U.S. Department of Health and Human Services, U.S. Government Printing Office, Washington, D.C. (1992).
J.-H. Lin, et al., "Physiological Disposition and Metabolism of L-735,524, A Potent HIV Protease Inhibitor in Laboratory Animals", Pharmaceutical Research., 10(10), suppl., p. S-374 (1993).
B.V. Sheety, et al., "Preclinical Pharmacokinetics and Distribution to Tissue of AG1343, an Inhibitor of Human Immunodeficiency Virus Type 1 Protease", Antimicrob. Agents Chemother., 40(1), pp. 110-114 (1996).
WPI abstract No. C94-046567 of WO 94/05639(Bhisetti et al.). 1994.
Medline abstract No. 00115308, Portegies, Drugs (New Zealand) 49 Suppl 1, pp. 25-31. 1995.
Medline abstract No. 00094568, Tozzi et al., AIDS (United States), 7(5) pp. 683-692. 1993.
Medline abstract No. 00121958, Chiesi et al., J. Acquir. Immune Defic. Syndr. Hum. Retrovirol.(United States), 11(1) pp. 39-44. 1995.
Isselbacher et al. "Harrison's Principles of Internal Medicine", vol. 2, published by McGraw-Hill, pp. 1589-1591. 1994.
Haley, Jr. James F.
Henley III Raymond
Hsi Jeffrey D.
Vertex Pharmaceuticals Incorporated
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