Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Patent
1994-11-30
1997-03-11
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
424422, A61K 600, A61K 700
Patent
active
056098774
ABSTRACT:
The present invention relates to the employment of melatonin in the preparation and use of pharmaceuticals effective in the treatment of the articular symptoms of rheumatoid arthritis.
REFERENCES:
patent: 4309415 (1982-01-01), Horrobin
Wei Wei et al. "Regulatory effects of pineal gland and melatonin on inflammatory and immune responses", Advances in Pineal Research vol. 7 pp. l 131-136.
XU Shu-Yun et al. "Effects of total glucosides of paeony and moutan cortex on the functions of pineal gland in infolammatory-immune regulations in rats", Chinese Journal of Pharmacology vol. 8 No. 3, pp. 161-165, 1994.
Stanley K. West et al. "Melatonin Levels are Decreased in Rheumatoid Arthritis", Journal of Basics, vol. 3 No. 1, pp. 33-40, 1992.
M. Martinuzzo et al. "Melatonin effect on arachidonic acid metabolism to cyclooxygenase derivatives in human platelets", Journal of Pineal Research, vol. 11 No. 3/4 pp. 111-115, 1991.
Marek Paelikowski et al. "Melatonin inhibits Prostaglandin E Release From the Medial Basal Hypothalamus of Pinealectomized Rats", Journal of Pineal Research, vol. 1 No. 4, pp. 317-321, 1984.
Catherine M. Leach et al. "A comparison of the inhibitory effects of melatonin and indomethacin on platelet aggregation and thromboxane release", Prostaglandins, vol. 20 No. 1, 1980.
James E. F. Reynolds "Martindale, The Extra Pharmacopoeia", The Pharmaceutical Press, pp. 22-24, 1989.
Ana M. Franchi et al. "Melatonin, 5-methoxytryptamine and some of their analogs as cyclooxygenase inhibitors in rat medial basal hypothalamus", Brain Research, vol. 3 No. 2, pp. 384-388, 1987.
Howard Sharon
Page Thurman K.
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