Treatment of T cell mediated autoimmune disorders

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof

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4241301, 4241331, 4241411, 4241421, 4241431, 4241441, 4241534, 4241731, A61K 39395

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058339876

ABSTRACT:
Method for the treatment of multiple sclerosis and other T cell mediated autoimmune disorders is described. The method involves administering to a subject a therapeutically effective amount of an antagonist of a receptor on a surface of a T cell which mediates contact dependent helper effector functions, for example, an anti-gp39 antibody.

REFERENCES:
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Durie et al. (1993) Science vol. 261 (5126):1328-30.
Mohan et al. (Apr. 24-28, 1994) FASEB Journal vol. 8 (4-5):A967.
Durie et al. (Oct. 1994) Clinical Immunopathol. vol. 73(1): 11-18.
Laman et al. (Oct. 23-27, 1994) Journal of Neuroimmunology vol. 54 (1-2):. 5
Harris et al. (1993) Tibtech vol. 11:42-44.
Queen et al. (1989) Proc. Natl. Acad. Sci. vol. 86:10029-33.

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