Treatment of systemic fungal infections with phospholipid partic

Details Treatment of systemic fungal infections with phospholipid partic Treatment of systemic fungal infections with phospholipid partic

1995-06-06

1999-02-23

Preselev, Elli

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

514 31, A61K 9127, A61K 3170

Patent

active

058741046

ABSTRACT:
Formulations consisting of phospholipid small unilamellar particles encapsulating polyene antifungal antibiotics and methods for using such compositions to treat systemic fungal infections are described. In a preferred embodiment, the particles are in the form of vesicles which comprise a polyene antifungal antibiotic, preferably amphotericin B and/or nystatin, egg phosphatidylcholine and cholesterol, preferably in the molar ratio of about 0.2 (AMB):2(PL):1(CHOL). These vesicles may also have an amine modified surface. The vesicles are suspended in a low isonic strength saccharide/tris solution at a pH of from about 6.0 to about 8.0 and may be administered to deliver the antifungal antibiotic to treat systemic fungal infections.

REFERENCES:
patent: 4753788 (1988-06-01), Gamble
patent: 4766046 (1988-08-01), Abra et al.
patent: 4812312 (1989-03-01), Lopez-Berestein et al.

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