Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1990-02-26
1991-12-03
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
A61K 31495
Patent
active
050700847
ABSTRACT:
Method of diagnosing and treatment of sympathetically maintained pain. Sympathetically maintained pain is diagnosed and treated using the method of injecting or transdermally applying an .alpha.-adrenergic blocking agent selected from the group consisting of .alpha.-adrenergic antagonist, .alpha.-1-adrenergic antagonist, .alpha.2 adrenergic agonist, or other drug that depletes sympathetic norepineprhine. Sympathetic efferent fibers release norepinephrine which in turn activates .alpha.-adrenergic receptors. Activation of these receptors, either directly or indirectly, excites nociceptors. Activity in the nociceptors then evokes pain, and causes further discharge of nociceptors. Intravenous administration of phentolamine blocks the activation of .alpha.-adrenergic receptors which causes the pain to be relieved. The use of a clonidine, another .alpha.-adrenergic blocking agent, in a patch similarly achieved substantive pain reduction.
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