Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-07-02
1996-05-21
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514369, 514211, 514279, 514253, A61K 3147
Patent
active
055190359
ABSTRACT:
Administration of protein kinase C inhibitors protect neuronal cells from death from cerebral ischemia. Model for screening compounds for potential for protecting neuronal cells from death from cerebral ischemia comprises adding the compounds to medium containing neuronal cells before, at the same time as, and/or after nitric oxide administration.
REFERENCES:
patent: 4940694 (1990-07-01), della Valle et al.
patent: 5204370 (1993-04-01), Jiang et al.
patent: 5266594 (1993-11-01), Dawson et al.
patent: 5344841 (1994-09-01), Jiang et al.
AN 111:90221. Joo, F., et al, "Inhibition by H-7 of the Protein Kinese C Prevents Formation of Brain Edema in Sprague-Dawley CFY rats", Brain Research (1989), 490(1), 141-143.
Hara, H., et al, "Staurosporine, a Novel Protein Kinase C Inhibitor, Prevents Neuronal Damage in the Gerbil and Rat", J. Cereb. Blood Flow Metab. (1990), 10(5), 646-653, Chem. Abstract AN 114:480 CA.
Ohono et al, "Effect of Staurosporine, a PKC Inhibitor, on Impairment of Working Memory in Rats Exposed to Cerebral Ischemia", Eur. J. Pharm 29 Oct. 1991 204(1) 113-6. AN 92209620.
Nixon, J. S., et al, Agents and Actions, 32, 3/4, 188-193 (1991).
Hannun, Y. A., et al, J. Biol. Chem., 261, 12604-12609 (1986).
Kawamoto, S., et al, Biochem. Biophys. Res. Commun. 125, 258-264 (1984).
Program for International Meeting on Microcirculatory Stasis in the Brain, Tokyo, Japan, May 20-21, 1993.
Program for International Symposium on Cerebral Blood Vessel '93, Mt. Zao, Japan, May 28-30, 1993.
Mattson M., Experimental Neurology, 112, 95-103 (1991).
Nakane, M., et al, Biochem. Biophys. Res. Commun, 180, 1396-1402, Nov. 1991.
Knowles, R. G., et al, Biochem J., 269: 207-210 (1990).
Nowicki, J. P., et al, Euro. J. Pharm. 204, 339-340 (1991).
Dawson, V. L., et al, Proc. Natl. Acad. Sci, USA 88, 6368-6371 (1991).
Endoh, M., et al, Neuroscience letters 154, 125-128 (1993).
Favaron, M., et al, Proc. Natl. Acad. Sci. USA 85, 7351-7355 (Oct. 1988).
Lancaster, J. R., American Scientist, 80, 248-257 (May-Jun. 1992).
Mattson et al, M. P., et al, The Journal of Neuroscience, 8(6), 1087-2100 (Jun. 1988).
Sato, S., Biochimica et Biophysica Acta, 1181, 195-197 (1993).
Bredt, D. S., et al, Proc. Natl. Acad. Sci. USA, vol. 86, 9030-9033, Nov. 1989.
Bredt, D. S., et al, The Journal of Biological Chemistry, vol. 267, No. 16, 10976-10981, Jun. 1992.
Favaron, M., et al, Proc. Natl. Acad. Sci. USA, vol. 87, 1938-1987, Mar. 1990.
Garthwaite, J., et al, European Journal of Pharmacology--Molecular Pharmacology Section, 172, 413-416 (1989).
Hidaka, H., et al, Biochemistry, 23, 5036-5041, 1984.
Knowles, R. G., Proc. Natl. Acad. Sci. USA, vol 86, 5159-5162, Jul. 1989.
Maiese, K., et al, Soc. Neurosci. Abst., 18(2), 1453, presented Oct. 30, 1992.
Maiese, K., et al, Presentation at International Meeting on Microcirculatory Stasis, Tokyo, Japan, May 20, 1993, entitled "Down-Regulation of Protein Kinase C is Neuroprotective During Nitric Oxide Toxicity".
McKenna et al, U.S. Statutory Invention Registration H1168, published Apr. 6, 1993.
Rothman, S. M., et al, Annals of Neurology, vol. 19, No. 2, Feb. 1986, pp. 105-111.
Maiese Kenneth
Wagner John A.
Cintins Marianne M.
Cornell Research Foundation Inc.
MacMillan Keith
LandOfFree
Treatment of stroke or in anticipation of the occurrence of brai does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Treatment of stroke or in anticipation of the occurrence of brai, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment of stroke or in anticipation of the occurrence of brai will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2038321