Treatment of stress and preconditioning against stress

Details Treatment of stress and preconditioning against stress Treatment of stress and preconditioning against stress

1998-09-11

2000-10-24

Witz, Jean C.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Animal or plant cell

435 2, 435366, 435372, C12N 506

Patent

active

061363081

ABSTRACT:
Symptoms of stress such as elevated blood pressure in mammals are treated, and mammalian bodies are preconditioned to manifest reduced adverse reactions to subsequently encountered stresses, by injecting into the mammalian patient a small quantity of the patient's own blood which has been previously extracted and subjected extracorporeally to at least one stressor, such as ultraviolet radiation, an oxidative environment, ozone-oxygen and mild heating, especially infra-red radiation causing mild heating. Particularly beneficial combinations of stressors are simultaneous applications of UV radiation and an ozone-oxygen gas mixture bubbled through the blood sample to provide the oxidative environment, or simultaneous application of UV radiation, ozone-oxygen gas mixtures and mild heating. One specific use of the invention is in preconditioning against ischemic-reperfusion injury, e.g. prior to surgery.

REFERENCES:
patent: 4968483 (1990-11-01), Muller et al.
patent: 5591457 (1997-01-01), Bolton
patent: 5891653 (1999-04-01), Attfield
patent: 5906636 (1999-05-01), Casscells, III et al.
Perdrizet, G. A. et al., "Heat Shock and Recovery Protects Renal Allografts from Warm Ischemic Injury and Enhances HSP72 Production," Transplantation Proceedings vol. 25, No. 1: pp. 1670-1673, Feb. 1993.
Nishina, H. et al., "Stress-signalling kinase SEK 1 Protects Thymocytes from Apoptosis Mediated by CD 95 and CD 3," Nature, vol. 385, No. 1614, Jan. 1997.

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