Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-08-15
2006-08-15
Navarro, Mark (Department: 1645)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
Reexamination Certificate
active
07091332
ABSTRACT:
The present invention relates to an improved approach for the treatment of microbial infections in mammals. Specifically, the invention provides methods and reagents for expressing in mammalian cells proteins that have anti-microbial activity. The invention provides both genes which have been modified to allow expression and preferably secretion of active protein in desired mammalian cells or tissues, and methods of introducing such modified genes into desired mammalian cells and/or tissues. Most specifically, genes encode anti-staphylococcal proteins are delivered to mammalian cells and/or tissues by methods of gene delivery, including gene therapy and the production of transgenic animals, for the treatment of mastitis in ruminant animals.
REFERENCES:
patent: 4931390 (1990-06-01), Recsei
patent: 5011772 (1991-04-01), Recsei
patent: 5124145 (1992-06-01), Sordillo et al.
patent: 5189015 (1993-02-01), Höök et al.
patent: 5234684 (1993-08-01), Sordillo et al.
patent: 5342612 (1994-08-01), Daley et al.
patent: 5607919 (1997-03-01), Bojsen et al.
patent: 5824869 (1998-10-01), Broekaert et al.
patent: 6028051 (2000-02-01), Climo et al.
patent: 6204020 (2001-03-01), Ladner et al.
patent: 0 359 873 (1988-09-01), None
patent: 0 759 473 (1995-08-01), None
patent: WO 87/06264 (1987-10-01), None
patent: 96/35793 (1996-11-01), None
patent: WO 96/35793 (1996-11-01), None
patent: WO 99/05289 (1999-02-01), None
Houdebine, et al.,Journal of Biotechnology, “Production of Pharmaceutical Proteins from Transgenic Animals”, 34:269-287, 1994.
Mullins, et al.,Hypertension, “Transgenesis in Nonmurine Species,” 22: 630-633, 1993.
Wall, et al.,J. Dairy Sci., “Transgenic Dairy Cattle: Genetic Engineering on a Large Scale,” 80:2213-2224.
Archer, et al., “Human Growth Hormone (hGH) Secretion in Milk of Goats After Direct Transfer of the hGH Gene into the Mammary Gland by Using Replication-Defective Retrovirus Vectors”,Proc. Natl.Acad. Sci.91: 6840-44, Jul. 1994.
Auldist, et al., “Changes in the Composition of Milk from Healthy and Mastitic Dairy Cows During the Lactation Cycle”,Aust. J. Exp. Agricul.35: 427-36, 1995.
Auldist, et al., “Effect of Somatic Cell Count and Stage of Lactation on the Quality and Storage Life of Ultra High Temperature Milk”,J. Dairy Res.63: 377-386, 1996.
Barbano, et al., “Influence of Milk Somatic Cell Count and Milk Age on Chesse Yield”,J. Dairy Sci.74: 369-88, 1991.
Bramley, et al., “Effects of Lysostaphin onStaphylococcus aureusInfections of the Mouse Mammary Gland”,Research in Veterinary Science, 49:120-21; 1990.
Bramley, et al., “Reviews of the Progress of Dairy Science: Mastitis Control—Progress and Prospects”Journal of Dairy Research, 51, 481-512, 1984.
Chandler, “Experimental Bacterial Mastitis in the Mouse”,J. Med. Microbiol.3: 273-82, 1970.
Chomczynski, et al., “Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate-Phenol-Chloroform Extraction”,Anal. Biochem.162: 156-59, 1987.
Craven, et al., “Phagocytosis ofStaphylococcus aureusby Bovine Mammary Gland Macrophages and Intracellular Protection from Antibiotic Action in Vitor and In Vivo”,J. Dairy Res.51: 513-23, 1984.
Craven, et al., “Antibiotic Activity Against IntraleukocyticStaphylococcus aureusin Vitro and In Experimental Mastitis in Mice”,Am. J. Vet. Res, 44:(4), 709-12, 1983.
Daley, et al., “Lysostaphin: Immunogenicity of Locally Administered Recombinant Protein Used in Mastitis Therapy”,Veterinary Immunology and Immunopathology, 31:301-12, 1992.
Derbyshire, et al., “Immunization Against ExperimentalStaphylococcal mastitisin the Goat by the Intramammary Infusion of Cell-Toxoid Vaccine”Res. Vet. Sci., 10:559-64, 1969.
Ebert, et al., “Transgenic Production of a Variant of Human Tissue-Type Plasminogen Activator in Goat Milk: Generation of Transgenic Goats and Analysis of Expression”,Bio/Technology, 9: 835-38, 1991.
Gordon, et al., “Production of Human Tissue Plasminogen Activator in Transgenic Mouse Milk”,Bio/Technology, 5: 1183-87, 1987.
Harmon, et al., “Concentration of Lactoferrin in Milk of Normal Lactating Cows and Changes Occurring during Mastitis”Am. J. Vet. Res.36: 1001-1007, 1975.
Heinrich, et al., “The Molecular Organization of the Lysostaphin Gene and its Sequences Repeated in Tandem”,Mol. Gen Genet, 209:563-69, 1987.
Jacob, et al., “Potential Therapeutic Applications of Magainins and Other Antimicrobial Agents of Animal Origin”,Ciba. Found. Symp.186: 197-216, discussion, 216-23, 1994.
Kagan, et al., “Defensins: A Family of Antimicrobial and Cytotoxic Peptides”,Toxicology, 87: 131-49, 1994.
Kerr, et al., “Expression of Gene-gun Injected Plasmid DNA in the Ovine Mammary Gland and In Lymph Nodes Draining the Injection Site” Animal Biotechnology 7:33-45, 1996.
Klei, et al., “Effects of Milk Somatic Cell Count on Cottage Cheese Yield and Quality”,J. Dairy Sci.81:1205-13, 1998.
Kossaibati, et al., “Incidence of Clinical Mastitis in Dairy Herds in England”,Vet. Rec.143:649-53, 1998.
Krimpenfort, et a., “Generation of Transgenic Dairy Cattle Using ‘In Vitro’ Embryo Production”Bio/Technology, 9: 844-47, 1991.
Liang, et al., “Molecular Cloning and Nucleotide Sequence of the β-Lytic Protease Gene from Achromobacter Lyticus”Journal of Bacteriology, 172(11):6506-11; 1990.
Maga, et al., “Antimicrobial Properties of Human Lysozyme Transgenic Mouse Milk”,J. Food Prot.61: 52-56, 1998.
Maga, et al., “The Effect of Mammary Gland Expression of Human Lysozyme on the Properties of Milk From Transgenic Mice”,J. Dairy Sci.78: 2645-52, 1995.
Myllys, et al., “Bovine Mastitis in Finland in 1988 and 1995—Changes in Prevalence and Antimicrobial Resistance”,Acta Vet. Scand.39: 119-126, 1998.
Nickerson, et al., “Symposium: Mastitis in Dairy Heifers, Mastitis in Dairy Heifers: Initial Studies on Prevalence and Control”,J Dairy Sci, 78:1607-18, 1995.
Nuijens, et al., “Characterization of Recombinant Human Lactoferrin Secreted in Milk of Transgenic Mice”J. of Biol. Chemi., 272 (13): 8802-07, 1997.
Oldham, et al., “Lysostaphin: Use of a Recombinant Bactericidal Enzyme as a Mastitis Therapeutic”,J. Dairy Sci., 74:4175-82, 1991.
Platenburg, et al., “Expression of Human Lactoferrin Milk of Transgenic Mice”,Transgenic Res.3:99-108, 1994.
Plaut, et al., “Integration of the IacZ Gene into the Mammary Gland Using an Adenovirus Vector”,J. Dairy Sci., 80:1, 1997.
Recsei, et al., “Cloning, Seguence, and Expression of the Lysostaphin Gene From Staphylococcus Simulans”,Proc. Natl. Acad. Sci., USA, 84: 1127-31, 1987.
Reiter, B., “Review of the Progress of Dairy Science: Antimicrobial Systems in Milk”,J. Dairy Res.45: 131-47, 1978.
Schindler, et al., Lysostaphin: A New Bateriolytic Agent For theStaphyloccus. Proc. Natl. Acad. Sci. U.S.A.51:414-421, 1964.
Schnieke, et al., “Human Factor IX Transgenic Sheep Produced by Transfer of Nuclei From Transfected Fetal Fibroblasts”,Science, 278:2310-33, 1997.
Shockman, et al., “Stucture, Function, and Assembly of Cell Walls of Gram-Positive Bacteria”,Annu. Rev. Microbiol.37: 501-27, 1983.
Sutra, et al., “Virulence Factors Involved in the Pathogenesis of Bovine Intramammary Infections Due toStaphylococcus aureaus”, J. Med. Microbiol.40: 79-89, 1994.
Takahashi, et al., “Nonspecific Antibacterial Factors in Milk from Cows Immunized with Human Oral Bacterial Pathogens”,J. Dairy Sci.75:1810-20, 1992.
Thumm, et al., “Studies on Prolysostaphin Processing and Characterization of the Lysostaphin Immunity Factor (Lif) ofStaphulococcus Simulans Biovar Staphylolyticus” Molecular Microbiology, 26(6), 1251-6
Bramley A. John
Kerr David
Plaut Karen I.
Choate Hall & Stewart LLP
Herschbach Jarrell Brenda
Navarro Mark
University of Vermont
LandOfFree
Treatment of staphylococcus infections does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Treatment of staphylococcus infections, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment of staphylococcus infections will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3713195