Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1999-06-16
2000-05-09
Cook, Rebecca
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514256, 514543, A61K 3120
Patent
active
060605154
ABSTRACT:
Disorders of the skin and mucous membrane that have a disrupted or dysfunctional epidermal barrier are treated or prevented by topical application of compounds that are either activators of the farnesoid X receptor, activators of the peroxisome proliferator-activated receptor .alpha., and oxysterol activators of the LXR.alpha. receptor. The same compounds are also effective in treating disorders of epidermal differentiation and proliferation.
REFERENCES:
CA 126:142392, Arts et al., 1997.
Forman et al. Cell (Jun. 2, 1995) 81: 687-693.
Hanley et al. The Journal of Investigative Dermatology (Mar. 1996) 106(3): 404-411.
Imakado et al. Genes Dev. (1995) 9(3): 317-329.
Schmidt et al. Lipids (1996) 31(11): 1115-1124.
Schoonjans et al. Journal of Lipid Research (1996) 37: 907-925.
Weinberger TEM (1996) 7(1): 1-6.
Yang et al. Br. J. Dermatol. (1995) 133(5): 679-685.
Bass Nathan N.
Elias Peter M.
Feingold Kenneth R.
Hanley Karen
Cook Rebecca
The Regents of the University of California
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