Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ether doai
Patent
1998-08-04
2000-03-21
Cook, Rebecca
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ether doai
A61K 3108
Patent
active
060403470
DESCRIPTION:
BRIEF SUMMARY
The subject-matter of the present invention is the use of octoxyglycerol in a cosmetic or dermatological composition for treating seborrhoea and cutaneous disorders which are associated with it, in particular acne and/or hyperseborrhoea.
The secretion of sebum is a normal phenomenon and useful to the skin and the hair. However, the hypersecretion of sebum, known as seborrhoea, is annoying and sometimes results in a cutaneous pathology, in particular a greasy skin and even one suffering from acne, and a seborrhoeic condition of the scalp. The consequences of the sebaceous hypersecretion and the disturbance of the keratinization of the pilo-sebaceous follicle is that the pilo-sebaceous follicle becomes blocked and that retentional lesions or comedones are formed.
These pathologies and in particular acne and/or hyperseborrhoea relate in particular to the colonization of the skin or hair follicle by microorganisms of the genus Propionibacterium, such as Propionibacterium acnes, Propionibacterium granulosum or Propionibacterium avidum.
These undesirable microorganisms metabolize sebum triglycerides, with the release of the irritant fatty acids responsible for the inflammation which appears during these pathologies.
Use is commonly made, in combating these pathogenic agents, of active agents such as triclosan, hexamidine, hexetidine and benzalkonium chloride. However, the use of these active agents is not without side effects. Thus, triclosan exhibits a not insignificant toxicity, even by the topical route. In addition, it has proved to be insufficiently effective, in particular in certain vehicles where its activity is inhibited by the surfactants. Hexamidine and hexetidine, in the form of salts, are sensitizing substances capable of causing allergies. Furthermore, benzalkonium chloride can prove to be irritating at the normal doses of use. Moreover it destabilizes compositions containing anionic surfactants.
It is thus found that the need remains for topical active agents which have an effect on the pathologies related to microorganisms of the genus Propionibacterium and which have an action at least as effective as the compounds of the prior art, while not exhibiting the disadvantages of the known compounds.
The subject-matter of the present invention is precisely the use of specific compounds which make it possible to obtain this effect.
The Applicant Company has discovered that octoxyglycerol exhibited high activity with respect to Propionibacterium acnes and Propionibacterium granulosum and could thus be used in a cosmetic or dermatological composition as anti-seborrhoeic and anti-acne active agent.
The document DE-A-4,140,474 certainly describes the use of monoalkyl ethers of glycerol in compositions for cleansing and caring for the skin. However, these compounds are used as supergreasing additives which prevent the drying of the skin in alcohol-based antiseptic and disinfectant compositions, the monoalkyl ethers of glycerol reinforcing the antiseptic effect of the alcohol while preventing the drying of the skin. The use of monoalkyl ethers of glycerol, particularly of octoxyglycerol, to act against pathologies related to Propionibacterium acnes and Propionibacterium granulosum, and in particular to treat seborrhoea and acne, has never been described.
The document WO 93/25208 describes the use of monoalkyl ethers of glycerol in cytocidal, antibacterial and spermicidal compositions. This document does not specifically describe the activity of the monoalkyl ethers with respect to microorganisms of the genus Propionibacterium and still less pathologies related to Propionibacterium acnes and Propionibacterium granulosum and in particular seborrhoea and acne. Moreover, octoxyglycerol is not cited in this document.
The subject-matter of the present invention is thus the use of octoxyglycerol in a cosmetic composition for treating seborrhoea of the skin and/or of the scalp and/or cutaneous disorders associated with seborrhoea.
Another subject-matter of the present invention is the use of octoxyglycerol in the ma
REFERENCES:
Database WPI, Week 8108, Derwent Publications Ltd., London, GB; AN 81-1255ld, XP002036883, "Stable aq. powder dispersion cosmetic-obtd. by dispersing powder in gel obtd, by addn. of sucrose fatty acid ester, alpha monoglycerineether and surfactant to water", Dec. 13, 1980.
Cupferman Sylvie
Laugier Jean-Pierre
Cook Rebecca
Societe l'Oreal S.A.
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