Treatment of schizophrenia with ampakines and neuroleptics

Details Treatment of schizophrenia with ampakines and neuroleptics Treatment of schizophrenia with ampakines and neuroleptics

1998-10-26

2000-12-26

Jones, Dwayne C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142292, 514249, 514321, 514338, 514354, 514410, 514411, 514423, A61K 31535

Patent

active

061660086

ABSTRACT:
This invention relates to treatment of schizophrenia and related psychotic disorders, including enhancement of receptor functioning in synapses in brain networks responsible for higher order behaviors. In a particular aspect, the invention relates to methods for the use of AMPA receptor up-modulators in conjunction with antipsychotics for the treatment of schizophrenia. Kits containing the compositions in appropriate form for administration are also provided.

REFERENCES:
Vanover of the abstract to, "Effects of AMPA receptor positive modulators on amphetamine- and dizocilpine-induced locomotion", European Journal of Pharmacology, vol. 332, Issue: 2, Aug. 6, 1997.

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