Treatment of sarcoma with interleukin 1.alpha. polypeptides

Details Treatment of sarcoma with interleukin 1.alpha. polypeptides Treatment of sarcoma with interleukin 1.alpha. polypeptides

1992-09-30

1994-12-27

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

424 852, 530351, 930141, A61K 3702

Patent

active

053766393

ABSTRACT:
DNAs encoding polypeptides having interleukin 1, vectors inserted with said DNAs, hosts transformed with said recombinant vectors, polypeptides having interleukin 1 activity which are produced by cultivation of the transformed hosts, derivatives of the polypeptides, pharmaceutical composition containing said polypeptides or derivatives, their use as an antitumor or antiinfectious agent, and processes for the preparation thereof.

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Auron, et al. (1984) Lymphokine Research 3, 285.
Auron, et al. (1984) Proc. Natl. Acad. Sci. USA 81, 7907.
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Lomedico, et al. (1984) Nature 312, 458.
March, et al. (1985) Nature 315, 641.
Mosley, et al. (1985) Progress in Leukocyte Biology 2, 521.
Scala, et al. (1984) Nature 309, 56.
Durum et al., Ann. Rev. Immunol 1985, 3, pp. 263-287.
Immunophysical: The Rate of Cells and Cytakines in Immunity and Inflammation, Opperheim et al., 1990, pp. 210-214.

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