Treatment of rumen acidosis with α-amylase inhibitors

Details Treatment of rumen acidosis with α-amylase inhibitors Treatment of rumen acidosis with α-amylase inhibitors

2007-09-18

2007-09-18

Lewis, Patrick (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S025000, C514S057000, C514S060000, C514S061000

Reexamination Certificate

active

10774139

ABSTRACT:
The invention described herein relates to: the use of an effective inhibitor of a bacterial α-amylase and/or α-glucosidase in the manufacture of a composition for the treatment of acidosis; a method of treatment of rumen acidosis which comprises administration of an effective amount of an effective inhibitor of a bacterial α-amylase and/or α-glucosidase to a ruminant; a formulation suitable for the treatment of acidosis in an animal which comprises an effective inhibitor of a bacterial α-amylase and/or α-glucosidase in admixture with a suitable excipient, diluent or carrier selected with regard to the intended route of administration and standard pharmaceutical/veterinary/farming practice; screening methods useful in the identification of a suitable inhibitor of a bacterial α-amylase and/or α-glucosidase for the treatment of acidosis in a ruminant; a process for improving ruminant milk quality and/or quantity which comprises treatment of a ruminant with an effective amount of an inhibitor of bacterial α-amylase and/or α-glucosidase; a compound of the formula I:or veterinarily acceptable salt, solvate (including hydrate) or prodrug thereof; and processes to make an effective inhibitor of a bacterial α-amylase and/or α-glucosidase useful for the treatment of acidosis in a ruminant.

REFERENCES:
patent: 4062950 (1977-12-01), Frommer et al.
patent: 4175123 (1979-11-01), Junge et al.
patent: 4618602 (1986-10-01), Vertesy et al.
patent: 4885361 (1989-12-01), Wessel
patent: 648326 (1985-03-01), None
patent: 19821038 (1999-11-01), None
patent: 0049981 (1984-07-01), None
patent: 0194794 (1986-09-01), None
patent: 0089812 (1986-10-01), None
patent: 0240175 (1991-10-01), None
patent: 0520557 (1992-12-01), None
patent: 0599646 (2002-09-01), None
patent: 556500 (1986-06-01), None
patent: 1482543 (1974-09-01), None
patent: 2000-44589 (2000-02-01), None
patent: 2001-59657 (2001-03-01), None
patent: WO9620945 (1996-07-01), None
“New α-Amylase Inhibitor, Trestatins, III Structure Determination of New Trestatin Components Ro 09-0766, Ro 09-0767, and Ro 09-0768”,Journal of Antibiotics, pp. 182-186 (1984).
Barbaud, et al., “Synthesis of the Frist Pseudosugar-C-disaccharide. A Potential Antigen for Eliciting Glycoside-bond Forming Antibodies with Catalytic Groups”,Tetrahedron51(33), pp. 9063-9078 (1995).
Berge, et al., “Pharmaceutical Salts”,Journal of Pharmaceutical Sciences66(1), pp. 1-19 (1977).
Blanc-Muesser, et al., “Syntheses Stereoselectives de 1-Thioglycosides”,Carbohydrate Res67, pp. 305-328 (1978).
Bornaghi, et al., “Transfer Reactions Catalyzed by cyclodextrin Glucosyltransferase Using 4-Thiomaltosyl and C-maltosyl Fluorides as Artificial Donors”,Carbohydrate Res.305, pp. 561-568 (1997).
Chatterjee, et al., “Glucosidation of Betulinic Acid by Cunninghamella Species”,J. Nat. Prod.62, pp. 761-763 (1998).
Coe, et al., “Effect of Virginiamycin on Ruminal Fermentation in Cattle During Adaptation to a High Concentrate Diet and During an Induced Acidosis”,J. Anim. Sci77, pp. 2259-2268 (1999).
Crout, et al., “Glycosidases and Blycosyl Tranferases in Glycoside and Oligosaccharide Synthesis”,Curr Opinion in Chem Biol.2, pp. 989-111 (1998).
Evers, et al., “Further Syntheses Employing Phsophorylase”,Bioorg.&Medic. Chem5(5), pp. 857-863 (1997).
Fukuhara, et al., “Isolation and Structure-activity Relationship of Some Amylostatins (F-1b Fraction) Produced by Streptomyces diastaticus subsp. Amylostaticus No. 940”,Agric. Biol. Chem.46(7), pp. 1941-1945 (1982).
Hormi, et al., “Experimental Studies of Lewis Acid Catalyzed Additions of Long Chained Alchohols to Activated 1,4-Benzoquinone”,Tetrahedron54, pp. 1943-1952 (1998).
Garcia-Granados, et al., “Biotransformation of ENT-6α-Acetoxy- and ENT-6-Ketomanoyl Oxides with Rhizopus Nigricans and Curvularia Lunata Cullures”,Phytochemistry45(2), pp. 283-291 (1997).
Kim, et al., “Comparative Study of the Inhibition of α-Glucosidase, α-Amylase, and Cyclomaltodextrin Glucanosyltransferase by Acarbose, Isoacarbose, and Acarviosine-Glucose”,Archives of Biochemistry and Biophysics371(2), pp. 277-283 (1999).
Kim et al, “Studies on Screening and Isolation of α-Amylase Inhibitors of Soil Microorganismis (II)”,Kor. J. Mycol.13(4), pp. 203-212 (1985).
Machius, et al., “Carbohydrate and Protein-based Inhibitors of Porcine Pancreatic α-Amylase: Structure Analysis and Comparison of Their Binding Characteristics”,J. Mol. Biol.260, pp. 409-421 (1996).
McAuliffe, et al., “β-Acarbose: A Potential Inhibitor of β-D-Glucosidases and β-D-Glucan Hydrolases”,Tetrahedron Letters37(14), pp. 2479-2482 (1996).
Oda, et al., “Double Coupling of Acetyl Coenzyme A Production and Microbial Esterification with Alcohol Acetyltransferase in an Interface Bioreactor”,Journ. Of Ferm. And Bioeng.83 (5), pp. 423-428 (1997).
Ogawa, et al., “Total Synthesis of Acarbose and Adiposin-2”,J. Chem. Soc. Chem. Commun.pp. 605-606 (1988).
Ohyama, et al., “Purification and Some Properties of Amylase Inhibitor (S-Al)”,Agric. Biol. Chem.41 (11), pp. 2221-2228 (1977).
Ott, et al., “A Method for Constructing the C44- C51 Side Chain of Altohyrtin C”,Org. Letters1(9), pp. 1475-1478 (1999).
Park, et al., “Transglycosylation Reactions ofBacillus stearothermophilusmaltogenic amylase with acarbose and various acceptor”,Carbohydrate Res.313, pp. 235-246 (1998).
Rauter, et al., “Deoxygenation at C-e and Stereospecific Branched-Chain Construction at C-3 of a Methyl Hexopranuloside. Synthetic Approach to the Amipurimycin Sugar Moiety”,J. Org. Chem.61, pp. 3594-3598 (1996).
Richard, et al., “Effect of Acarbose on Glucose and Insulin Response to Sucrose Load in Reactive Hypoglycemia”,Diabete&Metabolisme14, pp. 114-118 (1988).
Saleh, et al., “Preparation of (±)-1-Allyl-4-deoxy Mannose Derivatives”,Synlett5, pp. 617-619 (1999).
Shiozaki, et al., “Synthesis of (S)-and ®-3[(Benyloxycarbonyl)Oxy]-2,2-Difluorotetradecanoic Acid”,Tetrahedron: Asymmetry3(3), pp. 451-458 (1992).
Scigelova, et al., “Glycosidases—a Great Synthetic Tool”,Journ. Of Molecular Catalysis B: Enzymatic6, pp. 483-494 (1999).
Sariaslani, et al., “Novel Biotransformations of 7-Ethoxycoumarin byStreptomyces griseus”, Appl. And Envir. Microbiol.46(2), pp. 468-474 (1983).
Takada, et al., “Chemo-Enzymatic Synthesis of Galactosylmaltooligosaccharidonolactone as a Substrate Analogue Inhibitor for Mammalian α-Amylase”,J. Biochem123, pp. 508-515 (1998).
Truscheit, et al., “Chemistry and Biochemistry of Microbial α-Glucosidase Inhibitors”,Angew. Chem. Int. Ed.20, pp. 744-761 (1981).
Uchida, et al., “Synthesis of New N-Containing Maltooligosaccharides, α-Amylase Inhibitors, and Their Biological Activities”,Chem. Pharm. Bull47(2), pp. 187-193 (1999).
Yokose, et al., “New α-Amylase Inhibitor, Trestatins II. Structure Determination of Trestatins A, B, and C”,The Journal of Antibiotics, pp. 1166-1175 (1983).
“Validamycin H, A New Pseudo-Tetrasaccharide Antibiotic”,The Journal of AntibioticsXLIII(8), pp. 1039-1041 (1990).
“Validamycin G and Validoxylamine G, New Members of the Validamycins”,The Journal of AntibioticsXXXIX(10), pp. 1491-1495 (1986).
Microbial Blycosidation of Validamycins,The Journal of AntibioticsXXXI(9), pp. 936-938 (1978).
Asano, et al., “All Eight Possible Mono-β-D-Glucosides of Validoxylamine A”,The Journal of Antibiotics44(12), pp. 1406-1416 (1991).
Asano, et al., “Trehalase Inhibitors, Validoxylamine A and Related Compounds as Insecticides”,The Journal of AntibioticsXLIII(6), pp. 722-726 (1990).
Bl

Affiliated with

Also associated with

Rating

Treatment of rumen acidosis with α-amylase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Treatment of rumen acidosis with α-amylase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment of rumen acidosis with α-amylase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3750091