Treatment of rumen acidosis with α-amylase inhibitors

Details Treatment of rumen acidosis with α-amylase inhibitors Treatment of rumen acidosis with α-amylase inhibitors

2006-04-04

2006-04-04

Wilson, James O. (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S017200, C536S018700, C536S123100

Reexamination Certificate

active

07022684

ABSTRACT:
The invention described herein relates to: the use of an effective inhibitor of a bacterial α-amylase and/or α-glucosidase in the manufacture of a composition for the treatment of rumen acidosis; a method of treatment of rumen acidosis which comprises administration of an effective amount of an effective inhibitor of a bacterial α-amylase and/or α-glucosidase to a ruminant; a formulation suitable for the treatment of rumen acidosis in an animal which comprises an effective inhibitor of a bacterial α-amylase and/or α-glucosidase in admixture with a suitable excipient, diluent or carrier selected with regard to the intended route of administration and standard pharmaceutical/veterinary/farming practice; screening methods useful in the identification of a suitable inhibitor of a bacterial α-amylase and/or α-glucosidase for the treatment of acidosis in a ruminant; a process for improving ruminant milk quality and/or quantity which comprises treatment of a ruminant with an effective amount of an inhibitor of bacterial α-amylase and/or α-glucosidase; a compound of the formula I:or veterinarily acceptable salt, solvate (including hydrate) or prodrug thereof; and processes to make an effective inhibitor of a bacterial α-amylase and/or α-glucosidase useful for the treatment of acidosis in a ruminant.

REFERENCES:
patent: 4062950 (1977-12-01), Frommer et al.
patent: 4175123 (1979-11-01), Junge et al.
patent: 4273765 (1981-06-01), Suhara et al.
patent: 4618602 (1986-10-01), Vertesy et al.
patent: 4885361 (1989-12-01), Wessel
patent: 648326 (1985-03-01), None
patent: 19821038 (1999-11-01), None
patent: 0049981 (1984-07-01), None
patent: 0194794 (1986-09-01), None
patent: 0089812 (1986-10-01), None
patent: 0240175 (1991-10-01), None
patent: 0520557 (1992-12-01), None
patent: 0599646 (2002-09-01), None
patent: 556500 (1986-06-01), None
patent: 1482543 (1974-09-01), None
patent: 2000-44589 (2000-02-01), None
patent: 2001-59657 (2001-03-01), None
patent: WO 9617525 (1996-06-01), None
patent: WO9620945 (1996-07-01), None
Malcolm Woodbine; Antimicrobials and Agriculture; The Proceedings of the 4thInternational Symposium on Antibiotics in Agriculture: Benefits and Malefits; (1984) 331-347.
Robinson, et al.; Influence of Carbohydrate Source and Buffer on Rumen Fermentation Characteristic, Milk Yield, and Milk Composition in Early-Lactation Holstein Cows; Journal of Dairy Science (1999) 82:2486-2496.
Kung et al.; Preventing In Vitro Lactate Accumulation in Ruminal Fermentations by Inoculation withMegasphaera elsdenii;Journal of Animal Science; (1995) 72:250-256.
Scott A. Martin; Manipulation of Ruminal Fermentation with Organic Acids: A Review; Journal of Animal Science (1995) 76:3123-3132.
Martin, et al.; Effects of DL-Malate on Ruminal Metabolism and Performance of Cattle Fed a High-Concentrate Diet; Journal of Animal Science (1999) 77:1008-1015.
Teather, et al.; Manipulating the Rumen Microflora with Bacteriocins to Improve Ruminant Production; Canadian Journal of Animal Science (1998) 78 (supplement) pp. 57-69.
The Use of Drugs in Food Animals: Benefits and Risks; CABI publishing (1999).
Thorniley, et al.; A single drench of virginiamycin to increase safety of feeding grain to sheep; Australian Journal of Agricultural Research; (1998) 49:899-906.
Wiryawan, et al.; Probiotic control of lactate accumulation in acutely grain-fed sheep; Australian Journal of Agricultural Research; (1995) 46:1555-1568.
Kay, et al.; The Relationship between the Acidity of the Rumen Contents and Rumenitis, in Calves fed on Barley; Research in Veterinary Science; (1969) 10:181-187.
McManus, et al.; Microlesions on Rumen Papillae of Sheep Fed Diets of Wheat Grain; Research in Veterinary Science; (1977) 22:135-137.
Lameness Cost UK Dairy Herds—NMR; Animal Pharm. No. 417 (1999) p. 6.
Burrin, et al.; Response to Monensin in Cattle During Subacute Acidosis; Journal of Animal Science (1986) 63:888-893.
Coe, et al.; Effect of Virginiamycin on Ruminal Fermentation in Cattle During Adaptation to a High Concentrate Diet and During an Induced Acidosis; Journal of Animal Science (1999) 77:2259-2268.
Dirksen; Acidosis Physiology of Digestion and Metabolism in the Ruminant; Proceedings of the Third International Symposium Cambridge, England (1969) ED. A.T. Phillipson, Oriel Press.
Nagaraja, et al.; Nutrition and Disease; Veterinary Clinics of North America: Food Animal Practice (1998) 41(2) 257-277.
Nagaraja, et al.; Effect of Ionophore Antibiotics on Experimentally Induced Lactic Acidosis in Cattle; Am. J. of Veterinary Research (1985) 46(12) 2444-2452.
Nocek; Bovine Acidosis; Implications on Laminitis; J. of Dairy Science (1997) 80:1005-1028.
Nordlund, et al.; Herd-based Rumenocentesis: A Clinical Approach to the Diagnosis of Subacute Rumen Acidosis; Compendium on Continuing Education for the Practicing Veterinarian; (1995) p. 48-56.
Owens, et al.; Acidosis in Cattle: A Review, J. of Animal Science (1998) 76:275-286.
“New α-Amylase Inhibitor, Trestatins, III Structure Determination of New Trestatin Components Ro 09-0766, Ro 09-0767, and Ro 09-0768”,Journal of Antibiotics,pp. 182-186 (1984).
Barbaud, et al., “Synthesis of the First Pseudosugar-C-disaccharide. A Potential Antigen for Eliciting Glycoside-bond Forming Antibodies with Catalytic Groups”,Tetrahedron51(33), pp. 9063-9078 (1995).
Berge, et al., “Pharmaceutical Salts”,Journal of Pharmaceutical Sciences66(1), pp. 1-19 (1977).
Blanc-Muesser, et al., “Syntheses Stereoselectives de 1-Thioglycosides”,Carbohydrate Res67, pp. 305-328 (1978).
Bornaghi, et al., “Transfer Reactions Catalyzed by cyclodextrin Glycosyltransferase Using 4-Thiomaltosyl and C-maltosyl Fluorides as Artificial Donors”,Carbohydrate Res.305, pp. 561-568 (1997).
Chatterjee, et al., “Glucosidation of Betulinic Acid by Cunninghamella Species”,J. Nat. Prod.62, pp. 761-763 (1998).
Coe, et al., “Effect of Virginamycin on Ruminal Fermentation in Cattle During Adaptation to a High Concentrate Diet and During an Induced Acidosis”,J. Anim. Sci77, pp. 2259-2268 (1999).
Crout, et al., “Glycosidases and Blycosyl Transferases in Glycoside and Oligosaccharide Synthesis”,Curr Opinion in Chem Biol.2, pp. 969-111 (1998).
Evers, et al., “Further Syntheses Employing Phsophorylase”,Bioorg.&Medic. Chem5(5), pp. 857-863 (1997).
Fukuhara, et al., “Isolation and Structure-activity Relationship of Some Amylostatins (F-1b Fraction) Produced byStreptomyces diastaticussubsp.amylostaticusNo. 940”,Agric. Biol. Chem,46(7), pp. 1941-1945 (1982).
Hormi, et al., “Experimental Studies of Lewis Acid Catalyzed Additions of Long Chained Alchohols to Activated 1,4-Benzoquinone”,Tetrahedron54, pp. 1943-1952 (1998).
Garcia-Granados, et al., “Biotransformation of ENT-6α-Acetoxy- and ENT-6-Ketomanoyl Oxides withRhizopus nigricansandCurvularia lunataCultures”,Phytochemistry45(2), pp. 283-291 (1997).
Kim et al., “Comparative Study of the Inhibition of α-Glucosidase, α-Amylase, and Cyclomaltodextrin Glucanosyltransferase by Acarbose, Isoacarbose, and Acarviosine-Glucose”,Archives of Biochemistry and Biophysics371(2), pp. 277-283 (1999).
Kim et al, “Studies on Screening and Isolation of α-Amylase Inhibitors of Soil Microorganismls (II)”,Kor. J. Mycol,13(4), pp. 203-212 (1985).
Machius, et al., “Carbohydrate and Protein-based Inhibitors of Porcine Pancreatic α-Amylase: Structure Analysis and Comparison of Their Binding Characteristics”,J. Mol. Biol,260, pp. 409-421 (1996).
McAuliffe, et al., “β-Acarbose: A Potential Inhibitor of β-D-Glucosidases and β-D-Glucan Hydrolases”,Tetrahedron Letters37(14), pp. 2479-2482 (1996).
Oda, et al., “Double Coupling of Acetyl Coenzyme A Production and Microbial Esterification with Alcohol Acetyltransferase in an Interface Bioreactor”,Journ. Of Ferm. And B

Affiliated with

Also associated with

Rating

Treatment of rumen acidosis with α-amylase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Treatment of rumen acidosis with α-amylase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment of rumen acidosis with α-amylase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3555062