Treatment of radiation-damaged bone marrow using galactosyl cera

Details Treatment of radiation-damaged bone marrow using galactosyl cera Treatment of radiation-damaged bone marrow using galactosyl cera

1995-03-17

1998-06-16

Fonda, Kathleen K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 179, A61K 3170

Patent

active

057670927

ABSTRACT:
The present invention relates to a pharmaceutical composition (a marrow cell proliferation accelerator, a radioprotective agent, a therapeutic agent for thrombocytopenia) comprising a compound represented by the following formula (A), and to a therapeutic or prophylactic method (a method for accelerating marrow cell proliferation, a method for protecting human against radiation damage, a method for the treatment of thrombocytopenia) characterized in that an effective amount of a compound represented by the following formula (A) is administered to human: ##STR1## wherein R.sub.2 represents ##STR2## 26) or --(CH.sub.2).sub.7 CH=CH(CH.sub.2).sub.7 CH.sub.3, and R.sub.1, is one of the substituents defined by the following (a) to (d):
(a) --CH.sub.2 (CH.sub.2).sub.y CH.sub.3,
(b) --CH(OH)(CH.sub.2).sub.y (CH.sub.3).sub.2, and
(c) --CH(OH)(CH.sub.2).sub.y CH(CH.sub.3).sub.2, and
(d) --CH=CH(CH.sub.2).sub.y CH.sub.3
(wherein Y is an integer of 5-17).

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